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Similarities and differences in the effect of cocaine on α-adrenergic and muscarinic response

  • Animal and Human Physiology
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Abstract

Similarities and differences in the effect of cocaine on [alpha]-adrenergic and muscarinic receptors were shown in three experimental models. The postsynaptic stimulating effect of cocaine, mediated by [alpha]-adrenergic receptors was revealed in uninnervated chick amnion and innervated rat vas deferens. In vas deferens cocaine caused an increase of the amount of active [alpha]-adrenergic receptors, the appearance of an additional receptor pool, and change in the dimerization level. Cocaine acted as an antagonist on muscarinic receptors of the chick amnion. The inhibition by cocaine of muscarinic receptors in the rat brain cortex membranes led to a decrease in the number of receptors and their partial monomerization. Thus, cocaine influences both the [alpha]-adrenergic and the muscarinic response at the receptor level. Experiments on various objects have shown that cocaine activates the [alpha]-adrenergic response and inhibits the muscarinic one.

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  1. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia

    B. N. Manukhin, L. V. Berdysheva, O. V. Boiko & L. A. Nesterova

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  1. B. N. Manukhin
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  2. L. V. Berdysheva
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  3. O. V. Boiko
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  4. L. A. Nesterova
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Correspondence to B. N. Manukhin.

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Original Russian Text © B.N. Manukhin, L.V. Berdysheva, O.V. Boiko, L.A. Nesterova, 2011, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2011, No. 3, pp. 322–333.

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Manukhin, B.N., Berdysheva, L.V., Boiko, O.V. et al. Similarities and differences in the effect of cocaine on α-adrenergic and muscarinic response. Biol Bull Russ Acad Sci 38, 266–276 (2011). https://doi.org/10.1134/S1062359011030083

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