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Changes of glucocorticoid level in plasma and adrenal glands of pregnant rats and their offspring after antenatal stress of different etiology

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Abstract

We investigated the glucocorticoid level in plasma and adrenal glands of pregnant rats in the period of early organogenesis. Tests were performed 24 hours after stress of different etiology (acute hypobaric hypoxia, intermittent normobaric hypoxia, and immobilization) and then repeated in the adult offspring. There was a significant decrease in the glucocorticoid level in pregnant rats 24 hours after hypoxic stress. Various changes of the basal glucocorticoid level were found in the offspring after antenatal stress. Changes were mostly found in female offspring.

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Authors and Affiliations

  1. Biological Faculty, Human and Animal Physiology Department, Moscow State University, Leninskie Gory 1/12, Moscow, 119991, Russia

    L. K. Trofimova, A. A. Baizhumanov, E. N. Goncharenko, Ya. V. Krushinskaya, N. A. Sokolova & N. Yu. Kudryashova

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  1. L. K. Trofimova
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  2. A. A. Baizhumanov
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  3. E. N. Goncharenko
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  4. Ya. V. Krushinskaya
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  5. N. A. Sokolova
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  6. N. Yu. Kudryashova
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Correspondence to L. K. Trofimova.

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Original Russian Text © L.K. Trofimova, A.A. Baizhumanov, E.N. Goncharenko, Ya.V. Krushinskaya, N.A. Sokolova, N.Yu. Kudryashova, 2011, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2011, No. 1, pp. 101–106.

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Trofimova, L.K., Baizhumanov, A.A., Goncharenko, E.N. et al. Changes of glucocorticoid level in plasma and adrenal glands of pregnant rats and their offspring after antenatal stress of different etiology. Biol Bull Russ Acad Sci 38, 87–91 (2011). https://doi.org/10.1134/S1062359011010109

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  • DOI: https://doi.org/10.1134/S1062359011010109

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