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Mechanisms of hypothalamic-pituitary and immune system regulation: The role of gonadotropin-releasing hormone and immune mediators

  • Human and Animal Physiology
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Abstract

Different aspects of the reciprocal regulatory influence of systems producing the immune and gonadotropin-releasing hormone (GnRH) in pre- and postnatal ontogeny are discussed in this review. GnRH is a neurohormone synthesized by a small population of neurons located in the anterior hypothalamus, which regulates the secretion of gonadotropines in the anterior lobe of the pituitary gland and they finally regulate the synthesis of sex steroids. Particular attention is given to analysis of the data involving the role of thymic peptides and cytokines in GnRH-system regulation in the normal condition and in the case of inflammation development caused by endotoxines in adult animals. The main prospects of the studies involving the influence of proinflammatory cytokines on GnRH-neuron migration and differentiation in prenatal ontogenesis are also discussed.

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  1. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Vavilova St. 26, Moscow, 119991, Russia

    M. S. Izvol’skaya & L. A. Zakharova

  2. Moscow State University, GSP-1, Leninskie gory, Moscow, 119991, Russia

    V. S. Sharova

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  1. M. S. Izvol’skaya
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Original Russian Text © M.S. Izvol’skaya, V.S. Sharova, L.A. Zakharova, 2010, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2010, No. 4, pp. 451–461.

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Izvol’skaya, M.S., Sharova, V.S. & Zakharova, L.A. Mechanisms of hypothalamic-pituitary and immune system regulation: The role of gonadotropin-releasing hormone and immune mediators. Biol Bull Russ Acad Sci 37, 382–391 (2010). https://doi.org/10.1134/S1062359010040084

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