The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen.
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Original Russian Text © E.A. Kosenko, M.B. Abramova, N.I. Venediktova, I.I. Popova, Yu.G. Kaminskii, 2010, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2010, No. 4, pp. 411–416.
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Kosenko, E.A., Abramova, M.B., Venediktova, N.I. et al. The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biol Bull Russ Acad Sci 37, 346–350 (2010). https://doi.org/10.1134/S1062359010040035
- Biology Bulletin
- Mitochondrial Respiration
- Minimal Effective Concentration
- Succinate Oxidation