The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases
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The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen.
KeywordsBiology Bulletin Mitochondrial Respiration Minimal Effective Concentration Palmitoylcarnitine Succinate Oxidation
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