Abstract
Daily intramuscular injections of the arginine-heparin complex for 5 days before injection of diabetogenic metabolite alloxan did not cause insulin-dependent diabetes in animals for 3 weeks. As a result of these injections, the anticoagulant fibrinolytic pattern of the anticoagulant system was activated and the platelet aggregation decreased. This effect held for 7 days after injection.
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References
Aster, R.H., Heparin-Induced Immune Thrombocetopenia—A Clinical or Laboratory Diagnosis, Thrombosis Haemost., 2006, vol. 4, no. 4, pp. 757–758.
Astrup, T. and Mullertz, S., The Fibrin Plate Method for Estimating Fibrinolytic Activity, Arch. Biochem. Biophys., 1952, vol. 40, pp. 346–351.
Balabolkin, M.I., Morozova, T.N., and Chagiashvili, M.V., New Method of Treatment of Disturbances of the Homeostasis System in Patients of Type 1 Diabetes Mellitus in Tez. dokl. Vsesoyuzn. konf. “Aktual’nye problemy gemostaza v klinicheskoi praktike” (Abstr. All-Union Conf. “Topical Problems of Homeostasis in Clinical Practice), Moscow: Inst. Eksp. Endokrinol. Khim. Gormonov, 1987, pp. 9–10.
Barkagan, Z.S. and Kostyuchenko, G.I., Metabolic-Inflammatory Atherothrombosis Concept f and New Approaches to Treatment of Patients, Byul. Sib. Otd. RAMN, 2006, vol. 120, no. 2, pp. 132–138.
Barkagan, Z.S. and Mamot, A.P., Diagnostika i kontroliruemaya terapiya narushenii gemostaza (Diagnosing and Controlled Therapy of Homeostasis Disturbances), Moscow: N’yudiamed, 2001.
Berkovskii, A.L., Vasil’ev, S.A., Zherdeva, L.V., et al., Posobie po izucheniyu adgezivno-agregatsionnoi aktivnosti trombotsitov (Study of Platelet Aggregation and Adhesive Activity: A Manual), Moscow: RAMN, RENAM, 2003, pp. 3–28.
Brunini, T.M.C., Mendes-Ribeiro, A.C., Ellory, J.C., et al., Platelet Nitric Oxide Synthesis in Uremia and Malnutrition: A Role For L-Arginine Supplementation in Vascular Protection?, Cardiovasc. Res., 2007, vol. 73, no. 2, pp. 359–367.
Dolgov, V.V., Avdeeva, N.A., and Shchetnikovich, K.A., Metody issledovaniya gemostaza (Homeostasis Study Methods), Moscow: Izd. Min. Zdravookhr. Med. Prom. 1996.
Fujita, S., Rasmussen, B.B., Cadenas, J.G., et al., Effect of Insulin on Human Skeletal Muscle Protein Synthesis in Modulated by Insulin-Induced Changes in Muscle Blood Flow and Amino Acid Availability, Am. J. Physiol. Endocrinol. Metab, 2006, vol. 291, pp. E745–E754.
Kantorovich, L.S., Methods of Sugar Determination in Blood and Other Biological Fluids, Byul. Izobret. Tovarn. Znakov, 1963, no. 21.
Kudrjashov, B.A and Lyapina, L.A, in Thrombosis and Thrombolysis, Chazov, E.I. and Smirnov, V.N., Eds., New York: Consultants Bureau, 1986, pp. 33–65.
Kudryashov, B.A., Ashmarin, I.P., Lyapina, L.A., and Pastorova, V.E., Fibrinolytic and Anticoagulative Properties of the Complex of Low-Molecular-Weight Heparin with Aspirin, Byull. Eksp. Biol. Med., 1992, vol. 114, no. 12, pp. 609–611.
Kudryashov, B.A., The Toxic Action of the “Diabetogenic Factor” Metabolite in the Body during the Development of Insulin-Dependent Diabetes, Izv. Akad. Nauk, Ser. Biol., 1993, no. 5, pp. 694–791.
Nakayama-Hamada, M., Suzuki, A., Furukawa, H., et al., Citrullinated Fibrinogen Inhibits Thrombin-Catalysed Fibrin Polymerization, J. Biochem., 2008, vol. 144, no. 3, pp. 393–398.
Napoli, C., Stanley, W.C., and Ignarro, L.J., Nutrition and Cardiovascular Disease: Putting a Pathogenetic Framework into Focus, Cardiovasc. Res., 2007, vol. 73, no. 2, pp. 253–256.
Simonyan, A.V., Salamatov, A.A., Pokrovskaya, Yu.S., and Avanesyan, A.A., Ispol’zovanie ningidrinovoi reaktsii dlya kolichestvennogo opredeleniya ?-aminokislot v razlichnykh ob“ektakh. Metodicheskie rekomendatsii (The Use of the Ninhydrin Reaction for Quantitative Determination of α-Amino Acids in Different Objects), Volgograd: Volg-GMU, 2007.
Stief, T.W., Inhibition of Thrombin in Plasma by Heparin or Arginine, Clin. Appl. Thromb. Hemost., 2007, vol. 13, no. 2, pp. 146–153.
Ulyanov, A.M., Lyapina, L.A., Pastorova, V.E., and Smolina, T.Yu., Antidiabetic and Anticoagulant Properties of Heparin-Glutamic Acid Complex, Izv. Akad. Nauk, Ser. Biol., 2004, vol. 31, no. 3, pp. 340–344.
Vasilijevic, A., Buzadzic, B., Korac, A., et al., Beneficial Effects of L-Arginine-Nitric Oxide-Producing Pathway in Rats Treated with Alloxan, J. Physiol., 2007, vol. 584, pp. 921–933.
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Original Russian Text © A.M. Ul’yanov, T.Yu. Obergan, T.A. Shubina, V.E. Pastorova, L.A. Lyapina, 2010, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2010, No. 1, pp. 109–114.
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Ul’yanov, A.M., Obergan, T.Y., Shubina, T.A. et al. The protective effect of the arginine-heparin complex under simulation of insulin-dependent diabetes. Biol Bull Russ Acad Sci 37, 93–97 (2010). https://doi.org/10.1134/S1062359010010139
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DOI: https://doi.org/10.1134/S1062359010010139