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Toxic effect of Aβ25–35 and fullerene C60 on erythrocytes

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Abstract

Using light microscopy and spectrophotometry, it has been shown that amyloid β-peptide Aβ25–35 and water-soluble fullerene C60 cause lysis of human and rat erythrocytes. Both fullerene C60 and Aβ25–35 partly inhibited the activities of membrane-associated phosphofructokinase and cytoplasmic lactate dehydrogenase in erythrocytes.

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References

  • Bergmeyer, H.U. and Bernt, E, Lactate Dehydrogenase, in Methods of Enzymatic Analysis, Bergmeyer, H.U., Ed., Weinheim: Verlag Chemie, 1974, vol. 2, pp. 574–579.

    Google Scholar 

  • Chu, H. and Low, P.S., Mapping of Glycolytic Enzyme-Binding Sites on Human Erythrocyte Band 3, Biochem. J., 2006, vol. 400, no. 1, pp. 143–151.

    Article  PubMed  CAS  Google Scholar 

  • Haass, C., Schlossmacher, M., Hung, A.Y., et al., Amyloid Beta-Peptide Is Produced by Cultured Cells during Normal Metabolism, Nature, 1992, vol. 359, pp. 322–325.

    Article  PubMed  CAS  Google Scholar 

  • Huang, H.M., Ou, H.C., Hsieh, S.J., and Chiang, L.Y., Blockage of Amyloid Beta Peptide-Induced Cytosolic Free Calcium by Fullerenol-1 Carboxylate C60 in PC12 Cells, Life Sci., 2000, vol. 66, no. 16, pp. 1525–1533.

    Article  PubMed  CAS  Google Scholar 

  • Irizarry, M.C., Biomarkers of Alzheimer Disease in Plasma, NeuroRx, 2004, vol. 1, no. 2, pp. 226–234.

    Article  PubMed  Google Scholar 

  • Isakovic, A., Markovic, Z., Todorovic-Markovic, B., et al., Distinct Cytotoxic Mechanisms of Pristine versus Hydroxylated Fullerene, Toxicol. Sci., 2006, vol. 91, no. 1, pp. 173–183.

    Article  PubMed  CAS  Google Scholar 

  • Kaminskii, Yu.G., Venediktova, N.I., Marov, N.V., et al., Effect of β-Amyloid Peptides on Enzyme Activities Involved in Hydrogen Peroxide Metabolism in the Rat Brain, Neirokhimiya, 2007, vol. 24, no. 1, pp. 30–36.

    CAS  Google Scholar 

  • Karajanagi, S.S., Vertegel, A.A., Kane, R.S., and Dordick, J.S., Structure and Function of Enzymes Adsorbed onto Single-Walled Carbon Nanotubes, Langmuir, 2004, vol. 20, no. 26, pp. 11594–11599.

    Article  PubMed  CAS  Google Scholar 

  • Kim, J.E. and Lee, M., Fullerene Inhibits Beta-Amyloid Peptide Aggregation, Biochem. Biophys. Res. Commun., 2003, vol. 303, no. 2, pp. 576–579.

    Article  PubMed  CAS  Google Scholar 

  • Kosenko, E., Kaminsky, Y., Kaminsky, A., et al., Superoxide Production and Antioxidant Enzymes in Ammonia Intoxication in Rats, Free Radic. Res., 1997, vol. 27, pp. 637–644.

    Article  PubMed  CAS  Google Scholar 

  • Kuo, Y.M., Kokjohn, T.A., Kalback, W., et al., Amyloid-Beta Peptides Interact with Plasma Proteins and Erythrocytes: Implications for Their Quantitation in Plasma, Biochem. Biophys. Res. Commun., 2000, vol. 268, no. 3, pp. 750–756.

    Article  PubMed  CAS  Google Scholar 

  • Lewczuk, P., Esselmann, H., Bibl, M., et al., Electrophoretic Separation of Amyloid Beta Peptides in Plasma, Electrophoresis, 2004, vol. 25, no. 20, pp. 3336–3343.

    Article  PubMed  CAS  Google Scholar 

  • Mattson, M.P., Begley, J.G., Mark, R.J., and Furukawa, K., Aβ25–35 Induces Rapid Lysis of Red Blood Cells: Contrast with Aβ1–42 and Examination of Underlying Mechanisms, Brain Res., 1997, vol. 771, no. 1, pp. 147–153.

    Article  PubMed  CAS  Google Scholar 

  • Myagkova, M.A., Gavrilova, S.I., Lermontova, N.N., et al., The Ratio of Antibodies to β-Amyloid and Neurotransmitters in the Blood of Patients with Alzheimer’s Disease and with Senile Dementia of Alzheimer Type, Byull. Eksp. Biol. Med., 2001, vol. 131, no. 2, pp. 156–159.

    Article  Google Scholar 

  • Podolski, I.Ya., Podlubnaya, Z.A., Kosenko, E.A., et al., Effects of Hydrated Forms of C60 Fullerene on Amyloid 1-Peptide Fibrillization in Vitro and Performance of the Cognitive Task, J. Nanosci. Nanotechnol., 2007, vol. 7, no. 7, pp. 1479–1485.

    Article  PubMed  CAS  Google Scholar 

  • Robakis, N.K, β-Amyloid and Amyloid Precursor Protein: Chemistry, Molecular Biology, and Neuropathology, in Alzheimer’s Disease, Terry, R., Kattmann, R., and Bicke, E., Eds., N.Y.: Raven Press, 1994, pp. 317–326.

    Google Scholar 

  • Roher, A., Wolfe, D., Palutke, M., and KuKuruga, D., Purification, Ultrastructure, and Chemical Analysis of Alzheimer Disease Amyloid Plaque Core Protein, Proc. Natl. Acad. Sci. USA, 1986, vol. 83, pp. 2662–2666.

    Article  PubMed  CAS  Google Scholar 

  • Sayes, C.M., Gobin, A.M., Ausman, K.D., et al., Nano-C60 Cytotoxicity Is Due to Lipid Peroxidation, Biomaterials, 2005, vol. 26, no. 36, pp. 7587–7595.

    Article  PubMed  CAS  Google Scholar 

  • Seubert, P., Oltersdorf, T., Lee, M.G., et al., Secretion of Beta-Amyloid Precursor Protein Cleaved at the Amino Terminus of the Beta-Amyloid Peptide, Nature, 1993, vol. 361, no. 6409, pp. 260–263.

    Article  PubMed  CAS  Google Scholar 

  • Shoji, M., Golde, T.E., Ghiso, J., et al., Production of the Alzheimer Amyloid Beta Protein by Normal Proteolytic Processing, Science, 1992, vol. 258, no. 5079, pp. 126–129.

    Article  PubMed  CAS  Google Scholar 

  • Ui, M. and Sumi, T., Phosphofructokinase from Ehrlich Ascites Tumor, Methods Enzymol., 1982, vol. 90, pp. 35–38.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya ul. 3, Pushchino, Moscow Region, 142290, Russia

    I. N. Solomadin, N. V. Marov, N. I. Venediktova, E. A. Kosenko & Yu. G. Kaminsky

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  1. I. N. Solomadin
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  2. N. V. Marov
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  3. N. I. Venediktova
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  4. E. A. Kosenko
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  5. Yu. G. Kaminsky
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Corresponding author

Correspondence to Yu. G. Kaminsky.

Additional information

Original Russian Text © I.N. Solomadin, N.V. Marov, N.I. Venediktova, E.A. Kosenko, Yu.G. Kaminskii, 2008, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2008, No. 4, pp. 507–512.

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Solomadin, I.N., Marov, N.V., Venediktova, N.I. et al. Toxic effect of Aβ25–35 and fullerene C60 on erythrocytes. Biol Bull Russ Acad Sci 35, 436–440 (2008). https://doi.org/10.1134/S1062359008040171

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  • DOI: https://doi.org/10.1134/S1062359008040171

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