Abstract
The regulatory mechanisms of individual rat resistance to acute hypobaric hypoxia were studied using the functional indices of the central nervous system (neurochemical and behavioral) and the hematopoietic system. The resistance to hypoxia was evaluated by the time of attitudinal reflex maintenance and recovery after decompression to a simulated altitude of 11 200 m. Animals with different types of tolerance to hypoxia demonstrated different metabolic backgrounds of neurochemical processes (which were most balanced in moderately resistant rats). This agrees with the differences in active behavior and adaptive efficiency of these animals exposed to mild open-field stress. High functional activity of erythropoiesis and early leukocytic response were observed in hypoxia-tolerant rats.
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Original Russian Text © A.S. Shtemberg, M.G. Uzbekov, Yu.V. Farber, 2007, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2007, No. 4, pp. 444–453.
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Shtemberg, A.S., Uzbekov, M.G. & Farber, Y.V. Certain mechanisms of development of types of body tolerance to acute hypobaric hypoxia. Biol Bull Russ Acad Sci 34, 367–375 (2007). https://doi.org/10.1134/S1062359007040097
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DOI: https://doi.org/10.1134/S1062359007040097