Abstract
The dynamics of total protein and procollagen biosynthesis was studied in the muscle tissue in gunshot wound during the natural healing and after treatment with antioxidant (AO) 2,6-di-tert-butyl-4-methylphenol (BHT). AO treatment considerably decreased the rate of both total protein and procollagen synthesis in the muscle on the third day of healing. BHT notably decreased protein biosynthesis and inhibited corticosteroid production as measured from the electron spin resonance (ESR) signal of reduced adrenodoxin. AO treatment also decreased the rate of protein biosynthesis in bone marrow, thymus, and spleen. The decreased functional activity of the endocrine and immune systems suggests that AO considerably decelerates the systemic body response (general adaptation syndrome) to acute wound. Lipid peroxide radicals and the products of lipid hydroperoxide degradation are proposed as the primary mediators of the body response to stress.
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Original Russian Text © I.N. Todorov, G.N. Bogdanov, Yu.I. Mitrokhin, V.N. Varfolomeev, L.I. Sidorenko, D.V. Mishchenko, 2006, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2006, No. 6, pp. 680–687.
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Todorov, I.N., Bogdanov, G.N., Mitrokhin, Y.I. et al. An inhibitor of free radical processes decreases the rate of protein synthesis in gunshot wound tissues and decelerates the general adaptation syndrome. Biol Bull Russ Acad Sci 33, 553–558 (2006). https://doi.org/10.1134/S1062359006060045
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DOI: https://doi.org/10.1134/S1062359006060045