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Mixed-Mode Polymer Stationary Phases of Increased Hydrophilicity with Grafted Polyethyleneimine and Polyglycidol

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Abstract

Two methods for increasing the degree of hydrophilization and shielding of a resin substrate based on a styrene–divinylbenzene copolymer with attached polyethylenimine quaterinized with glycidol are proposed. The first method is the polymerization of glycidol in a functional layer by varying the pH of the reaction medium, and the second one is the modification of the substrate by oxidizing double bonds on its surface to form anchor epoxy groups. It is demonstrated that, in the first case, the optimal approach is to add glycidol twice before and after adding an alkali, because, in this case, the first addition of glycidol is consumed for the quaternization of the polyamine, and the second addition—for the polymerization in ion-exchange centers. The novel method of substrate modification in combination with the developed method for creating hydrophilic layers made it possible to significantly reduce the retention of oxohalides, haloacetic acids, and polarizable anions in the suppressed ion chromatography mode and amino acids in hydrophilic interaction liquid chromatography mode up to a change in the elution order. The obtained stationary phases are suitable for the simultaneous determination of standard inorganic anions, oxohalides, and haloacetic or alkylphosphonic acids in an ion chromatography mode, and also for the separation of amino acids, sugars, and vitamins in a hydrophilic interaction liquid chromatography mode.

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ACKNOWLEDGMENTS

The work was performed using the equipment of the Collective Use Center of Moscow State University “Technologies for obtaining new nanostructured materials and their comprehensive research”, acquired by Moscow State University under the program for updating the instrument base within the framework of the national project “Science” and within the framework of the Moscow State University Development Program.

Funding

The work was supported by the Russian Science Foundation, project no. 20-13-00140.

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, 119991, Moscow, Russia

    A. V. Gorbovskaia, E. K. Popkova, A. S. Uzhel & O. A. Shpigun

Authors
  1. A. V. Gorbovskaia
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  2. E. K. Popkova
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  3. A. S. Uzhel
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  4. O. A. Shpigun
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Corresponding author

Correspondence to A. S. Uzhel.

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Translated by V. Kudrinskaya

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Gorbovskaia, A.V., Popkova, E.K., Uzhel, A.S. et al. Mixed-Mode Polymer Stationary Phases of Increased Hydrophilicity with Grafted Polyethyleneimine and Polyglycidol. J Anal Chem 79, 464–475 (2024). https://doi.org/10.1134/S1061934824040063

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