Abstract
In this review, we provide an overview of methods for synthesizing magnetic nanoparticles (MNPs) with potential applications to biomedical research. We explore how the structure and properties of these particles are related to their diverse uses in medical diagnostics and bioanalysis. Special emphasis is placed on MNPs containing noble metals, which serve as biomarkers or active agents. Specifically, we focus on the application of direct and combined methods of atomic spectroscopy (ETAAS, AES/ICP–MS) to biomedical research. Experimental approaches to studying the behavior and transformations of MNPs in vitro and in vivo are considered. The importance of proper sample preparation in simulating the behavior of nanoparticles in biological media is highlighted. We also examine the significance of preparation techniques for the accurate determination of dissolved and nanosized forms in biological samples. Lastly, we assess the potential for the comprehensive studies of MNP behavior within complex biological systems, pointing toward future directions in this dynamic and promising field of research.
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Notes
Albumin is used to solve two problems: (1) to ensure the biocompatibility and reduce the toxicity of nanodrugs and (2) to release the loaded drug under the action of enzymes destroying the protective protein layer.
REFERENCES
Nochehdehi, A.R., Thomas, S., Sadri, M., Afghahi, S.S.S., and Mehdi Hadavi, S.M., J. Nanomed. Nanotechnol., 2017, vol. 8, no. 1, p. 423. https://doi.org/10.4172/2157-7439.1000423
Korolev, D.V., Doctoral (Chem.) Dissertation, St. Petersburg: Almazov Natl. Med. Res. Centre, 2019.
Sandler, S.E., Fellows, B., and Mefford, O.T., Anal. Chem., 2019, vol. 91, p. 14159. https://doi.org/10.1021/acs.analchem.9b03518
Ganta, S., Devalapally, H., Shahiwala, A., and Amiji, M., J. Controlled Release, 2008, vol. 126, no. 3, p. 187. https://doi.org/10.1016/j.jconrel.2007.12.017
Nanoparticles for Drug Delivery, Joshy, K.S., Sabu, Th., Vijay Kumar, Th., Eds., Singapore: Springer, 2021. https://doi.org/10.1007/978-981-16-2119-2
Xu, C. and Sun, S., Adv. Drug Delivery Rev., 2013, vol. 65, no. 5, p. 732. https://doi.org/10.1016/j.addr.2012.10.008
Zelepukin, I.V., Yaremenko, A.V., Ivanov, I.N., Yuryev, M.V., Cherkasov, V.R., Deyev, S.M., Nikitin, P.I., and Nikitin, M.P., ACS Nano, 2021, vol. 15, p. 11341. https://doi.org/10.1021/acsnano.1c00687
Handbook of Bioanalytics, Buszewski, B. and Baranowska, I., Cham: Springer, 2022. https://doi.org/10.1007/978-3-030-95660-8
ICP–MS and Trace Element Analysis as Tools for Better Understanding Medical Conditions, Arruda, M.A.Z. and de Jesus, J.R., Eds., Comprehensive Analytical Chemistry, vol. 97, Amsterdam: Elsevier, 2022. https://www.sciencedirect.com/science/journ-al/0166526X/97/ supp/C
Hurley, K.R., Ring, H.L., Kang, H., Klein, N.D., and Haynes, C.L., Anal. Chem., 2015, vol. 87, p. 11611. https://doi.org/10.1021/acs.analchem.5b02229
Anselmo, A.C. and Mitragotri, S., Bioeng. Transl. Med., 2019, vol. 4, no. 3, p. e10143. https://doi.org/10.1002/btm2.10143
Kharisov, B.I., Rasika Dias, H.V., Kharissova, O.V., Vazquez, A., Pena, Y., and Gomez, I., RSC Adv., 2014, vol. 4, no. 85, p. 45354. https://doi.org/10.1039/C4RA06902A
Xie, L., Jiang, R., Zhu, F., Liu, H., and Ouyang, G., Anal. Bioanal. Chem., 2014, vol. 406, no. 2, p. 377. https://doi.org/10.1007/s00216-013-7302-6
Pryazhnikov, D.V. and Kubrakova, I.V., J. Anal. Chem., 2021, vol. 76, no. 6, p. 685. https://doi.org/10.1134/S1061934821060095
Kudr, J., Haddad, Y., Richtera, L., Heger, Z., Cernak, M., Adam, V., and Zitka, O., Nanomaterials, 2017, vol. 7, no. 9, p. 243. https://doi.org/10.3390/nano7090243
Pryazhnikov, D.V., Kubrakova, I.V., Kiseleva, M.S., Martynov, L.Yu., and Koshcheeva, I.Ya., Mendeleev Commun., 2014, vol. 24, no. 2, p. 130. https://doi.org/10.1016/j.mencom.2014.03.023
Kubrakova, I.V. and Pryazhnikov, D.V., J. Anal. Chem., 2021, vol. 76, no. 1, p. 15. https://doi.org/10.1134/S1061934821010044
Mekseriwattana, W., Srisuk, S., Kriangsaksri, R., Niamsiri, N., and Prapainop, K., AAPS PharmSciTech, 2019, vol. 20, p. 55. https://doi.org/10.1208/s12249-018-1275-x
Timerbaev, A.R., Talanta, 2022, vol. 243, p. 123371. https://doi.org/10.1016/j.talanta.2022.123371
Nigam, S., Chandra, S., Newgreen, D.F., Bahadur, D., and Chen, Q., Langmuir, 2014, vol. 30, p. 1004. https://doi.org/10.1021/la404246h
Gaihre, B., Khil, M.S., Lee, D.R., and Kim H.Y., Int. J. Pharm., 2009, vol. 365, p. 180. https://doi.org/10.1016/j.ijpharm.2008.08.020
Lee, J.E., Lee, D.J., Lee, N., Kim, B.H., Choi, S.H., and Hyeon, T., J. Mater. Chem., 2011, vol. 21, p. 16869. https://doi.org/10.1039/C1JM11869B
N’Guyen, T.T.T., Duong, H.T.T., Basuki, J., Montembault, V., Pascual, S., Guibert, C., Fresnais, J., Boyer, C., Whittaker, M.R., Davis, T.P., and Fontaine, L., Angew. Chem., Int. Ed. Engl., 2013, vol. 52, p. 14152. https://doi.org/10.1002/anie.201306724
Yuan, L., Tang, Q., Yang, D., Zhang, J.Z., Zhang, F., and Hu, J., J. Phys. Chem. C, 2011, vol. 115, p. 9926. https://doi.org/10.1021/jp201053d
Shen, J., He, Q., Gao, Y., Shi, J., and Li, Y., Nanoscale, 2011, vol. 3, p. 4314. https://doi.org/10.1039/c1nr10580a
Pryazhnikov, D.V., Efanova, O.O., Kiseleva, M.S., and Kubrakova, I.V., Nanotechnol. Russ., 2017, vol. 12, p. 199. https://doi.org/10.1134/S1995078017020094
Liu, J., Detrembleur, C., De Pauw-Gillet, M.-C., Mornet, S., Van der Elst, L., Laurent, S., Jerome, C., and Duguet, E., J. Mater. Chem. B, 2014, vol. 2, p. 59. https://doi.org/10.1039/c3tb21229g
Ménard, M., Meyer, F., Affolter-Zbaraszczuk, C., Rabineau, M., Adam, A., Duenas Ramirez, P., Bégin-Colin, S., and Mertz, D., Nanotecnology, 2019, vol. 30, no. 17, p. 174001. https://doi.org/10.1088/1361-6528/aafe1c
Wang, Y., Wang, B., Liao, H., Song, X., Wu, H., Wang, H., Shen, H., Ma, X., and Tan, M., J. Mater. Chem. B, 2015, vol. 3, p. 7291. https://doi.org/10.1039/c5tb01197c
Jin, Y., Yue, X., Zhang, Q., Wu, X., Cao, Z., and Dai, Z., Acta Biomater, 2012, vol. 8, p. 3372. https://doi.org/10.1016/j.actbio.2012.05.022
Bixner, O. and Reimhult, E., J. Colloid Interface Sci., 2016, vol. 466, p. 62. https://doi.org/10.1016/j.jcis.2015.11.071
Pryazhnikov, D.V., Efanova, O.O., and Kubrakova, I.V., Mendeleev Commun., 2019, vol. 29, no. 2, p. 226. https://doi.org/10.1016/j.mencom.2019.03.038
Lu, S., Li, X., Zhang, J., Peng, C., Shen, M., and Shi, X., Adv. Sci., 2018, vol. 5, no. 12, p. 1801612. https://doi.org/10.1002/advs.201801612
Xu, C. and Sun, S., Adv. Drug Delivery Rev., 2013, vol. 65, p. 732. https://doi.org/10.1016/j.addr.2012.10.008
Rios, A. and Zougagh, M., TrAC, Trends Anal. Chem., 2016, vol. 84 A, p. 72. https://doi.org/10.1016/j.trac.2016.03.001
Alshehri, S., Imam, S.S., Rizwanullah, M., Akhter, S., Mahdi, W., Kazi, M., and Ahmad, J., Pharmaceutics, 2021, vol. 13, p. 24. https://doi.org/10.3390/pharmaceutics13010024
Timerbaev, A.R., Analyst, 2020, vol. 145, p. 1103. https://doi.org/10.1039/C9AN01920K
Ke, P.C., Lin, S., Parak, W.J., Davis, T.P., and Caruso, F., Decade of the protein corona, ACS Nano, 2017, vol, vol. 11, no. 12, p. 11773. https://doi.org/10.1021/acsnano.7b08008
Kulikova, G.A. and Parfenyuk, E.V., Prot. Met. Phys. Chem. Surf., 2010, vol. 46, no. 5, p. 546.
Winzen, S., Schoettler, S., Baier, G., Rosenauer, C., Mailaender, V., Landfester, K., and Mohr, K., Nanoscale, 2015, vol, vol. 7, no. 7, p. 2992. https://doi.org/10.1039/c4nr05982d
Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., and Dawson, K.A., Proc. Natl. Acad. Sci. U. S. A., 2008, vol. 105, no. 38, p. 14265. https://doi.org/10.1073/pnas.0805135105
Tenzer, S., Docter, D., Kuharev, J., Musyanovych, A., Fetz, V., Hecht, R., Schlenk, F., Fischer, D., Kiouptsi, K., Reinhardt, C., Landfester, K., Schild, H., Maskos, M., Knauer, S.K., and Stauber, R.H., Nat. Nanotechnol., 2013, vol, vol. 8, no. 10, p. 772. https://doi.org/10.1038/nnano.2013.181
Sikorski, J., Matczuk, M., Kaminska, A., Kruszewska, J., Trzaskowski, M., Timerbaev, A.R., and Jarosz, M., Int. J. Mol. Sci., 2022, vol. 23, p. 1088. https://doi.org/10.3390/ijms23031088
Rabel, M., Warncke, P., Grüttner, C., Bergemann, C., Kurland, H.-D., Müller, R., Dugandzic, V., Thamm, J., Muller, R., Popp, J., Cialla-May, D., and Fischer, D., Nanomedicine, 2019, vol. 14, p. 1681. https://doi.org/10.2217/nnm-2018-0382
Gutiérrez, L., Romero, S., Da Silva, G.B., Costo, R., Vargas, M.D., Ronconi, C.M., Serna, C.J., Veintemillas-Verdaguer, S., and Del Puerto Morales, M., Biomed. Eng., 2015, vol. 60, p. 417. https://doi.org/10.1515/bmt-2015-0043
Rojas, J.M., Gavilán, H., Del Dedo, V., Lorente-Sorolla, E., Sanz-Ortega, L., Da, SilvaG.B., Costo, R., Perez-Yagüe, S., Talelli, M., Marciello, M., Morales, M.P., Barber, D.F., and Gutiérrez, L., Acta Biomater., 2017, vol. 58, p. 181. https://doi.org/10.1016/j.actbio.2017.05.047
Yurenya, A., Nikitin, A., Garanina, A., Gabbasov, R., Polikarpov, M., Cherepanov, V., Chuev, M., Majouga, A., and Panchenko, V., J. Magn. Magn. Mater., 2019, vol. 474, p. 337. https://doi.org/10.1016/j.jmmm.2018.11.040
Mazuel, F., Espinosa, A., Luciani, N., Reffay, M., Le Borgne, R., Motte, L., Desboeufs, K., Michel, A., Pellegrino, T., Lalatonne, Y., and Wilhelm, C., ACS Nano, 2016, vol. 10, p. 7627. https://doi.org/10.1021/acsnano.6b02876
Sedykh, E.M., Dement’eva, O.V., Kartseva, M.E., Rumyantseva, T.B., Tunyan, A.A., Bannykh, L.N., Gromyak, I.N., and Rudoi, V.M., J. Anal. Chem., 2016, vol. 71, p. 62. https://doi.org/10.1134/S1061934816010123
Kruszewska, J., Sikorski, J., Samsonowicz-Gorski, J., and Matczuk, M., Anal. Bioanal. Chem., 2020, vol. 412, p. 8145. https://doi.org/10.1007/s00216-020-02948-3
Choi, M.M.F., Douglas, A.D., and Murray, R.W., Anal. Chem., 2006, vol. 78, no. 8, p. 2779. https://doi.org/10.1021/ac052167m
Zhang, Y., Shuang, S., Dong, C., Lo, C.K., Paau, M.C., and Choi, M.M.F., Anal. Chem., 2009, vol. 81, no. 4, p. 1676. https://doi.org/10.1021/ac8026349
Pace, H.E., Rogers, N.J., Jarolimek, C., Coleman, V.A., Higgins, C.P., and Ranville, J.F., Anal. Chem., 2012, vol. 84, p. 4633. https://doi.org/10.1021/ac201952t
Levy, M., Luciani, N., Alloyeau, D., Elgrabli, D., Deveaux, V., Pechoux, C., Chat, S., Wang, G., Vats, N., Gendron, F., Factor, C., Lotersztajn, S., Luciani, A., Wilhelm, C., and Gazeau, F., Biomaterials, 2011, vol. 32, p. 3988. https://doi.org/10.1016/j.biomaterials.2011.02.031
Montes-Bayón, M., Corte-Rodriguez, M., Álvarez-Fernández García, R., and Severo Fagundes, J., in Comprehensive Analytical Chemistry, vol. 97, Amsterdam: Elsevier, 2022, p. 109. https://doi.org/10.1016/bs.coac.2022.03.002
Ivask, A., Mitchell, A.J., Malysheva, A., Voelcker, N.H., and Lombi, E., Nanomed. Nanobiotechnol., 2018, vol. 10, p. e1486. https://doi.org/10.1002/wnan.1486
Yu, X., He, M., Chen, B., and Hu, B., Anal. Chim. Acta, 2020, vol. 1137, p. 191. https://doi.org/10.1016/j.aca.2020.07.041
Sun, Q.-X., Wei, X., Zhang, S.-Q., Chen, M.-L., Yang, T., and Wang, J.-H., Anal. Chim. Acta, 2019, vol. 1066, p. 13. https://doi.org/10.1016/j.aca.2019.03.062
García, R.A.-F., Corte-Rodríguez, M., Macke, M., LeBlanc, K., Mester, Z., Montes-Bayon, M., and Bettmer, J., Analyst, 2020, vol. 145, p. 1457. https://doi.org/10.1039/c9an01565e
Cao, Y., Feng, J., Tang, L., Yu, C., Mo, G., and Deng, B., Talanta, 2020, vol. 206, p. 120174. https://doi.org/10.1016/j.talanta.2019.120174
Amor, M., Tharaud, M., Gelabert, A., and Komeili, A., Environ. Microbiol., 2020, vol. 22, p. 823. https://doi.org/10.1111/1462-2920.14708
Wang, H., Wang, M., Wang, B., Zheng, L., Chen, H., Chai, Z., and Feng, W., Anal. Bioanal. Chem., 2017, vol. 409, p. 1415. https://doi.org/10.1007/s00216-016-0075-y
Liu, T., Bolea-Fernandez, E., Mangodt, C., De Wever, O., and Vanhaecke, F., Anal. Chim. Acta, 2021, vol. 1177, p. 338797. https://doi.org/10.1016/j.aca.2021.338797
Hieftje, G.M., Spectrochim. Acta, Part B, 2006, vol. 61, p. 597. https://doi.org/10.1016/j.sab.2006.05.006
Degueldre, C. and Favarger, P.-Y., Colloids Surf., A, 2003, vol. 217, p. 137. https://doi.org/10.1016/S0927-7757(02)00568-X
Laborda, F., Bolea, E., and Jiménez-Lamana, J., Trends Environ. Anal. Chem., 2016, vol. 9, p. 15.
Bolea, E., Jimenez, M.S., Perez-Arantegui, J., Vidal, J.C., Bakir, M., Ben-Jeddou, K., Gimenez-Ingalaturre, A.C., Ojeda, D., Trujilloa, C., and Laborda, F., Anal. Methods, 2021, vol. 13, p. 2742. https://doi.org/10.1039/d1ay00761k
Pace, H.E., Rogers, N.J., Jarolimek, C., Coleman, V.A., Higgins, C.P., and Ranville, J.F., Anal. Chem., 2011, vol. 83, p. 9361. https://doi.org/10.1021/ac201952t
Laborda, F., Bolea, E., Cepriá, G., Gómez, M.T., Jimenez, M.S., Pérez Arantegui, J., and Castillo, J.R., Anal. Chim. Acta, 2016, vol. 904, p. 10. https://doi.org/10.1016/j.aca.2015.11.008
Laborda, F., Gimenez-Ingalaturre, A.C., and Bolea, E., in Comprehensive Analytical Chemistry, vol. 93, Amsterdam: Elsevier, 2021, p. 35. https://doi.org/10.1016/bs.coac.2021.02.012
Abad-Alvaro, I., Pena-Vazquez, E., Bolea, E., Bermejo-Barera, P., Castillo, J.R., and Laborda, F., Anal. Bioanal. Chem., 2016, vol. 408, p. 5089. https://doi.org/10.1007/s00216-016-9515-y
Laborda, F., Gimenez-Ingalaturre, A.C., Bolea, E., and Castillo, J.R., Spectrochim. Acta, Part B, 2020, vol. 169, p. 105883. https://doi.org/10.1016/j.sab.2020.105883
Lee, S., Bi, X., Reed, R.B., Ranville, J.F., Herckes, P., and Westerhoff, P., Environ. Sci. Technol., 2014, vol. 48, p. 10291. https://doi.org/10.1021/es502422v
Vidmar, J., Oprčkal, P., Milačič, R., Mladenovič, A., and Ščančar, J., Sci. Total Environ., 2018, vol. 634, p. 1259. https://doi.org/10.1016/j.scitotenv.2018.04.081
Laycock, A., Clark, N.J., Clough, R., Smith, R., and Handy, R.D., Environ. Sci.: Nano, 2022, vol. 9, p. 420. https://doi.org/10.1039/d1en00680k
Laborda, F., Jimenez-Lamana, J., Bolea, E., and Castillo, J.R., J. Anal. At. Spectrom., 2013, vol. 28, p. 1220. https://doi.org/10.1039/C3JA50100K
Mozhayeva, D. and Engelhard, C., J. Anal. At. Spectrom., 2020, vol. 35, p. 1740. https://doi.org/10.1039/C9JA00206E
ISO/TS19590:2017: Nanotechnologies—Size Distribution and Concentration of Inorganic Nanoparticles in Aqueous Media via Single Particle Inductively Coupled Plasma Mass Spectrometry, 2017.
Nelson, J., Yamanaka, M., Lopez-Linares, F., Poirier, L., and Rogel, E., Energy Fuels, 2017, vol. 31, p. 11971. https://doi.org/10.1021/ACS.ENERGYFUELS.7B02380
Rua-Ibarza, A., Bolea-Fernandez, E., Pozo, G., Dominguez-Benetton, X., Vanhaecke, F., and Tirez, K., J. Anal. At. Spectrom., 2020, vol. 35, p. 2023. https://doi.org/10.1039/D0JA00183J
Temerdashev, Z.A., Galitskaya, O.A., Bol’shov, M.A., and Romanovskii, K.A., J. Anal. Chem., 2022, vol. 77, p. 53. https://doi.org/10.1134/S1061934822010130
Venkatesan, K., Rodríguez, B.T., Marcotte, A.R., Bi, X., Schoepf, J., Ranville, J.F., Herckes, P., and Westerhoff, P., Environ. Sci.: Water Res. Technol., 2018, vol. 4, p. 1923. https://doi.org/10.1039/C8EW00478A
Nwoko, K.C., Raab, A., Cheyne, L., Dawson, D., Krupp, E., and Feldmann, J., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2019, vol. 1124, p. 356. https://doi.org/10.1016/j.jchromb.2019.06.029
Sun, Y., Liu, N., Wang, Y., Yin, Y., Qu, G., Shi, J., Song, M., Hu, L., He, B., Liu, G., Cai, Y., Liang, Y., and Jiang, G., Anal. Chem., 2020, vol. 92, p. 14872. https://doi.org/10.1021/acs.analchem.0c02285
Bocca, B., Battistini, B., and Petrucci, F., Talanta, 2020, vol. 220, p. 121404. https://doi.org/10.1016/j.talanta.2020.121404
Van der Zande, M., Vandebriel, R.J., Van Doren, E., Kramer, E., Herrera, RiveraZ., Serrano-Rojero, C.S., Gremmer, E.R., Mast, J., Peters, R.J.B., Hol-lman, P.C.H., Hendriksen, P.J.M., Marvin, H.J.P., Peijnenburg, A.A.C.M., and Bouwmeester, H., ACS Nano, 2012, vol. 6, p. 7427. https://doi.org/10.1021/nn302649p
Logozzi, M., Mizzoni, D., Boccb, B., Di Raimo, R., Petrucci, F., Caimi, S., Alimonti, A., Falchi, M., Cappello, F., Campanella, C., Bavisotto, C.C., David, S., Bucchieri, F., Angelini, D.F., Battistini, L., and Fais, S., Eur. J. Pharm. Biopharm., 2019, vol. 137, p. 23. https://doi.org/10.1016/j.ejpb.2019.02.014
García, R.Á.-F., Fernández-Iglesias, N., López-Chaves, C., Sánchez-González, C., Llopis, J., Montes-Bayón, M., and Bettmer, J., J. Trace Elem. Med. Biol., 2019, vol. 55, p. 1. https://doi.org/10.1016/j.jtemb.2019.05.006
Ebeling, W., Hennrich, N., Klockow, M., Metz, H., Orth, H.D., and Lang, H., Eur. J. Biochem., 1974, vol. 47, p. 91. https://doi.org/10.1111/j.1432-1033.1974.tb03671.x
Bajorath, J., Hinrichs, W., and Saenger, W., Eur. J. Biochem., 1988, vol. 176, p. 441. https://doi.org/10.1111/j.1432-1033.1988.tb14301.x
Loeschner, K., Navratilova, J., Kobler, C., Molhave, K., Wagner, S., von der Kammer, F., and Larsen, E.H., Anal. Bioanal. Chem., 2013, vol. 405, p. 8185. https://doi.org/10.1007/s00216-013-7228-z
Johnson, M.E., Hanna, S.K., Bustos, A.R.M., Sims, C.M., Elliott, L.C.C., Lingayat, A., Johnston, A.C., Nikoobakht, B., Elliott, J.T., Holbrook, R.D., Scoto, K.C.K., Murphy, K.E., Petersen, E.J., Yu, L.L., and Nelson, B.C., ACS Nano, 2017, vol. 11, p. 526. https://doi.org/10.1021/acsnano.6b06582
Noireaux, J., Grall, R., Hullo, M., Chevillard, S., Oster, C., Brun, E., Sicard-Roselli, C., Loeschner, K., and Fisicaro, P., Separations, 2019, vol. 6, p. 3. https://doi.org/10.3390/separations6010003
Zhou, Q., Liu, L., Liu, N., He, B., Hu, L., and Wang, L., Ecotoxicol. Environ. Saf., 2020, vol. 198, p. 110670. https://doi.org/10.1016/j.ecoenv.2020.110670
Clark, N.J., Clough, R., Boyle, D., and Handy, R.D., Environ. Sci.: Nano, 2019, vol. 6, p. 3388. https://doi.org/10.1039/C9EN00547A
Ishizaka, T., Nagano, K., Tasaki, I., Tao, H., Gao, J.Q., Harada, K., Hirata, K., Saito, S., Tsujino, H., Higashisaka, K., and Tsutsumi, Y., Nanoscale Res. Lett., 2019, vol. 14, p. 180. https://doi.org/10.1186/s11671-019-3016-9
Vidmar, J., Buerki-Thurnherr, T., and Loeschner, K., J. Anal. At. Spectrom., 2018, vol. 33, no. 5, p. 752. https://doi.org/10.1039/C7JA00402H
Gao, Y., Zhang, R., Sun, H., Guo, Y., Chen, L., Shi, X., and Ge, G., Anal. Bioanal. Chem., 2022, vol. 414, p. 4401. https://doi.org/10.1007/s00216-022-03972-1
Fernandez-Trujillo, S., Rodríguez-Farinas, N., Jimenez-Moreno, M., and Martín-Doimeadios, R.D.C.R., Anal. Chim. Acta, 2021, vol. 1182, p. 338935. https://doi.org/10.1016/j.aca.2021.338935
Turiel-Fernandez, D., Gutiérrez-Romero, L., Corte-Rodríguez, M., Bettmer, J., and Montes-Bayón, M., Anal. Chim. Acta, 2021, vol. 1159, p. 338356. https://doi.org/10.1016/j.aca.2021.338356
Lores-Padín, A., Pereiro, R., and Fernández, B., in Recent Advances in Analytical Techniques, vol. 4, New York: Bentham, 2020, p. 1. https://doi.org/10.2174/9789811405112120040003
Metarapi, D., Sala, M., Vogel-Mikus, K., Selih, V.S., and Van Elteren, J.T., Anal. Chem., 2019, vol. 91, p. 6200. https://doi.org/10.1021/acs.analchem.9b00853
Metarapi, D., van Elteren, J.T., Sala, M., Vogel-Mikus, K., Arcon, I., Selih, V.S., Kolar, M., and Hocevar, S.B., Environ. Sci.: Nano, 2021, vol. 8, p. 647.
Sotebier, C.A., Kutscher, D.J., Rottmann, L., Jakubowski, N., Panne, U., and Bettmer, J., J. Anal. At. Spectrom., 2016, vol. 31, p. 2045.
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Kubrakova, I.V., Grebneva-Balyuk, O.N., Pryazhnikov, D.V. et al. Methods of Atomic Spectroscopy in Studying Properties and the Behavior of Nanoscale Magnetic Materials in Biological Systems. J Anal Chem 78, 1306–1319 (2023). https://doi.org/10.1134/S106193482310012X
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DOI: https://doi.org/10.1134/S106193482310012X