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Determination of Cetirizine Dihydrochloride in Tablets by Flow Injection Technique Using [Ag(HIO6)2]5−–H2SO4 Chemiluminescence System

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Abstract

A simple trivalent silver complex ([Ag(HIO6)2]5−) and sulfuric acid chemiluminescence (CL) reaction is established for cetirizine dihydrochloride determination in dosage form pharmaceuticals using flow injection technique. The possible CL reaction mechanism and enhancing influence of cetirizine are described based on spectrophotometric, spectrofluorimetric and CL spectra. The optimum experimental variables of the CL reaction were: 1.0 × 10–4 M silver(III) complex, 5.0 × 10–3 M H2SO4, 1.0 × 10–3 M KOH, 5.0 mL/min flow rate and 180 µL sample volume. The relative CL intensity was linear in the range of 0.1−20 mg/L (R2 = 0.9999, n = 7) with a limit of detection of 0.03 mg/L (S/N = 3), relative standard deviation of 1.6–3.4%, and injection frequency of 230/h. The suggested method has been successfully applied to monitor cetirizine concentration in various tablets and verified by the reported HPLC-UV approach that produces a recovery rate of 91.8–106%.

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REFERENCES

  1. Baltes, E., Coupez, R., Brouwers, L., and Gobert, J., J. Chromatogr. B: Biomed. Sci. Appl., 1988, vol. 430, p. 149.

    Article  CAS  Google Scholar 

  2. Rizk, N. M. H., Abbas, S. S., EL-Sayed, F. A., and Abo-Bakr, A., Int. J. Electrochem. Sci., 2009, vol. 4, p. 396.

    CAS  Google Scholar 

  3. Blaiss, M. S., Allergy Asthma Proc., 2005, vol. 26, no. 1, p. 95.

    CAS  PubMed  Google Scholar 

  4. El-Enin, M. A. A., J. Chem. Pharm. Res., 2016, 8, no. 9, p. 203.

    Google Scholar 

  5. Sher, N., Siddiqui, F. A., Hassan, N., Shafi, N., Zubair, A., and Mirza, A. Z., Anal. Methods, 2014, vol. 6, no. 8, p. 2704.

    Article  CAS  Google Scholar 

  6. Shamshad, H., Naz, A., and Mirza, A. Z., Anal. Bioanal. Chem. Res., 2021, vol. 8, no. 2, p. 139.

    CAS  Google Scholar 

  7. Shamshad, H., Sayqal, A., Zeb, J., and Mirza, A. Z., J. Chromatogr. Sci., 2021, vol. 59, no. 10, p. 923.

    Article  CAS  PubMed  Google Scholar 

  8. Katselou, M., Athanaselis, S., Nikolaou, P., Dona, A., Spiliopoulou, C., and Papoutsis, I., J. Pharm. Biomed. Anal., 2017, vol. 145, p. 765.

    Article  CAS  PubMed  Google Scholar 

  9. Haghighi, S., Shapouri, M. R., Amoli-Divab, M., Pourghazia, K., and Afruzi, H., Iran. J. Pharm. Res., 2013, vol. 12, no. 2, p. 303.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Azhagvuel, S. and Sekar, R., J. Pharm. Biomed. Anal., 2007, vol. 43, no. 3, p. 873.

    Article  CAS  PubMed  Google Scholar 

  11. Kowalski, P. and Plenis, A., Biomed. Chromatogr., 2007, vol. 21, no. 9, p. 903.

    Article  CAS  PubMed  Google Scholar 

  12. Youssef, A. F. and Farghali, R. A., Can. J. Anal. Sci. Spectrosc., 2006, vol. 51, no. 6, p. 288.

    CAS  Google Scholar 

  13. Javanbakht, M., Eynollahi Fard, S., Abdouss, M., Mohammadi, A., Reza Ganjali, M., Norouzi, P., and Safaraliee, L., Electroanalysis, 2008, vol. 20, no.18, p. 2023.

    Article  CAS  Google Scholar 

  14. Pushpanjali, P. A., Manjunatha, J. G., Sreeharsha, N., Asdaq, S. M. B., and Anwer, M., J. Mater. Sci: Mater. Electron., 2021, vol. 32, no. 17, p. 22668.

    CAS  Google Scholar 

  15. Al-Harbi, E. A., Int. J. Electrochem. Sci., 2021, vol. 16, p. 211036.

    Article  CAS  Google Scholar 

  16. Wang, L. S., Wei, X. L., Gong, Q., Jiang, Z. L., Li, D.M., and Liang, Q., Bull. Korean Chem. Soc., 2011, vol. 32, no. 2, p. 595.

    Article  Google Scholar 

  17. Cui, Y., Su, A., Feng, J., Dong, W., Li, J., Wang, H., Ni, X., and Jiang, Y., Spectrochim. Acta, Part A, 2022, vol. 264, p. 120293.

    Article  CAS  Google Scholar 

  18. Pourghazi, K., Khoshhesab, Z. M., Golpayeganizadeh, A., Shapouri, M. R., and Afrouzi, H., Int. J. Pharm. Pharm. Sci., 2011, vol. 3, p. 128.

    CAS  Google Scholar 

  19. Urs, S. S. R., Bindu, M., Ramyashree, D., and Sowmya, K., Asian J. Pharm. Anal., 2020, vol. 10, no. 4, p. 185.

    Google Scholar 

  20. Su, Y., Chen, H., Wang, Z., and Lv, Y., App. Spectrosc. Rev., 2007, vol. 42, no. 2, p. 139.

    Article  CAS  Google Scholar 

  21. Khan, M. S., Asghar, M., and Yaqoob, M., Anal. Sci., 2019, vol. 35, no. 8, p. 861.

    Article  CAS  PubMed  Google Scholar 

  22. Yousaf, M., Yaqoob, M., Asghar, M., and Ali, S., Chem. Res. Chin. Univ., 2019, vol. 35, no. 5, p. 775.

    Article  Google Scholar 

  23. Asghar, M., Yaqoob, M., and Nabi, A., Int. J. Environ. Anal. Chem., 2019, vol. 99, no. 7, p. 692.

    Article  CAS  Google Scholar 

  24. Asghar, M., Yaqoob, M., and Nabi, A., Int. J. Environ. Anal. Chem., 2017, vol. 97, no. 3, p. 276.

    Article  CAS  Google Scholar 

  25. Ahmed, M., Asghar, M., Yaqoob, M., Munawar, N., Shahid, F., Asad, M., and Nabi, A., Anal. Sci., 2017, vol. 33, no. 11, p. 1259.

    Article  CAS  PubMed  Google Scholar 

  26. Khan, A., Asghar, M., and Yaqoob, M., Anal. Sci., 2020, vol. 36, no. 10, p. 1223.

    Article  CAS  PubMed  Google Scholar 

  27. Christodouleas, D., Fotakis, C., Economou, A., Papadopoulos, K., Timotheou-Potamia, M., and Calokerinos, A., Anal. Lett., 2011, vol. 44, nos. 1-3, p. 176.

    Article  CAS  Google Scholar 

  28. Timofeeva, I. I., Vakh, C. S., Bulatov, A. V., and Worsfold, P. J., Talanta, 2018, vol. 179, p. 246.

    Article  CAS  PubMed  Google Scholar 

  29. Su, M., Chen, P., and Sun, H., TrAC, Trends Anal. Chem., 2018, vol. 100, p. 36.

    Article  CAS  Google Scholar 

  30. Al Lawati, H. A., Al Gharibi, E., Al Kindy, S. M., Suliman, F. E. O., and Al-Lawati, A. M., Talanta, 2011, vol. 85, no. 2, p. 906.

    Article  CAS  PubMed  Google Scholar 

  31. Mokhtari, A., Benam, M., Keyvanfard, M., and Ghazaeian, M., Anal. Bioanal. Chem. Res., 2016, vol. 3, no. 2, p. 265.

    CAS  Google Scholar 

  32. Kouhestany, R. H., Azizi, S. N., Shakeri, P., and Rahmani, S., Int. Curr. Pharm. J., 2016, vol. 5, no. 7, p. 59.

    Article  CAS  Google Scholar 

  33. Moazzam, M., Asghar, M., Yaqoob, M., Ali, S. and Nabi, A., Luminescence, 2021, vol. 36, no. 3, p. 674.

    Article  CAS  PubMed  Google Scholar 

  34. Balikungeri, A., Pelletier, M., and Monnier, D., Inorg. Chim. Acta, 1977, vol. 22, p. 7.

    Article  CAS  Google Scholar 

  35. Blikungeri, A. and Pelletier, M., Inorg. Chim. Acta, 1978, vol. 29, p. 141.

    Article  Google Scholar 

  36. Shen, S., Shi, H., and Sun, H., Acta Phys.-Chim. Sin., 2007, vol. 23, no. 3, p. 409.

    Article  CAS  Google Scholar 

  37. Sun, H., Chen, P., Wang, F., and Wen, H., Talanta, 2009, vol. 79, no. 2, p. 134.

    Article  CAS  PubMed  Google Scholar 

  38. Sun, H., Chen, P., and Wang, F., Anal. Lett., 2010, vol. 43, no. 14, p. 2234.

    Article  CAS  Google Scholar 

  39. Lin, J. M. and Yamada, M., Anal. Chem., 1999, vol. 71, no. 9, p. 1760.

    Article  CAS  PubMed  Google Scholar 

  40. Melwanki, M. B., Seetharamappa, J., Gowda, B. G., and Sajjan, A. G., Anal. Chem., 2001, vol. 46, no. 6, p. 883.

    CAS  Google Scholar 

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ACKNOWLEDGMENTS

The authors would like to thank the Analytical Chemistry Section, Department of Chemistry, University of Balochistan, Quetta, Pakistan for providing research facilities.

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Authors and Affiliations

  1. Department of Chemistry, University of Balochistan, 87300, Quetta, Pakistan

    Muhammad Moazzam, Muhammad Asghar, Mohammad Yaqoob, Samar Ali & Masood Ahmad Siddiqui

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  1. Muhammad Moazzam
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  2. Muhammad Asghar
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  3. Mohammad Yaqoob
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  4. Samar Ali
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  5. Masood Ahmad Siddiqui
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Correspondence to Mohammad Yaqoob.

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Moazzam, M., Asghar, M., Yaqoob, M. et al. Determination of Cetirizine Dihydrochloride in Tablets by Flow Injection Technique Using [Ag(HIO6)2]5−–H2SO4 Chemiluminescence System. J Anal Chem 78, 694–703 (2023). https://doi.org/10.1134/S1061934823060084

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