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An Experimental Design Approach for Optimization of Spectrophotometric Estimation of Mirabegron in Bulk and Pharmaceutical Formulations

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Abstract

Three simple, low-cost, sensitive and diversely applicable UV-Vis spectrophotometric methods have been developed for the estimation of drug Mirabegron. Method A is based on the reaction of Mirabegron with ninhydrin in the presence of sodium molybdate at pH 5.5. Method B is based on the reaction of the drug with 1,2-napthaquinone-4-sulphonate and cetyltrimethyl ammonium bromide in an alkaline medium. Method C is based on a redox reaction of the drug with Folin–Ciocalteu reagent in sodium carbonate medium. Beer’s law was obeyed in the concentration ranges of 2.5–22.5, 5–35, and 5–70 μg/mL for methods A, B, and C. The proposed methods can be applied to drug formulation and recommended for the routine analysis in quality control laboratories.

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Authors and Affiliations

  1. R & D Centre, Bharathiar University, Coimbatore; Department of Chemistry, Sapthagiri College of Engineering, Bangalore, India

    Roopa Kothathi Papanna

  2. Department of Chemistry, B.N.M. Institute of Technology, Bangalore, India

    Jayanna Bidarur Krishne Gowda

  3. Department of Studies in Chemistry, University of Mysore, Manasagangothri Mysore, India

    Padmarajaiah Nagaraja

Authors
  1. Roopa Kothathi Papanna
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  2. Jayanna Bidarur Krishne Gowda
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  3. Padmarajaiah Nagaraja
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Correspondence to Roopa Kothathi Papanna.

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Roopa Kothathi Papanna, Gowda, J.B. & Nagaraja, P. An Experimental Design Approach for Optimization of Spectrophotometric Estimation of Mirabegron in Bulk and Pharmaceutical Formulations. J Anal Chem 73, 884–893 (2018). https://doi.org/10.1134/S1061934818090095

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  • DOI: https://doi.org/10.1134/S1061934818090095

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