Journal of Analytical Chemistry

, Volume 73, Issue 7, pp 661–666 | Cite as

A Molibdenum(VI)–Gallein–Diphenhydramine Ion Associate and Its Application to the Extraction-Photometric Determination of Diphenhydramine

  • Kh. A. Mirzaeva
  • U. G. GamzaevaEmail author


Optimum conditions for the formation and extraction of a slightly soluble ion associate of diphenhydramine with the anionic complex molibydenum–gallein were determined. The ternary complex was extracted with butanol at pH 4–7. In the presence of diphenhydramine, the color strength became stronger, which was manifested in the absorption spectra as hypsochromic and bathochromic shifts. Some physicochemical characteristics of the complex were determined, the specificity of the reaction with respect to diphenhydramine was studied, and the probable complexation scheme was proposed. It was found that the molybdenum–gallein–diphenhydramine complex forms at a component ratio of 1: 2: 2. A procedure for the extraction–photometric determination of diphenhydramine in injection solutions and tablets was developed (RSD = 15–20%). The linearity range of the calibration graph was 0.02–0.20 mg/mL.


ion associate extraction spectrophotometry determination of diphenhydramine extraction molybdenum(VI) galleon 


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© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  1. 1.Faculty of ChemistryDagestan State UniversityMakhachkalaRussia
  2. 2.Dagestan State Medical UniversityMakhachkalaRussia

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