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Journal of Analytical Chemistry

, Volume 73, Issue 7, pp 661–666 | Cite as

A Molibdenum(VI)–Gallein–Diphenhydramine Ion Associate and Its Application to the Extraction-Photometric Determination of Diphenhydramine

  • Kh. A. Mirzaeva
  • U. G. GamzaevaEmail author
Articles
  • 21 Downloads

Abstract

Optimum conditions for the formation and extraction of a slightly soluble ion associate of diphenhydramine with the anionic complex molibydenum–gallein were determined. The ternary complex was extracted with butanol at pH 4–7. In the presence of diphenhydramine, the color strength became stronger, which was manifested in the absorption spectra as hypsochromic and bathochromic shifts. Some physicochemical characteristics of the complex were determined, the specificity of the reaction with respect to diphenhydramine was studied, and the probable complexation scheme was proposed. It was found that the molybdenum–gallein–diphenhydramine complex forms at a component ratio of 1: 2: 2. A procedure for the extraction–photometric determination of diphenhydramine in injection solutions and tablets was developed (RSD = 15–20%). The linearity range of the calibration graph was 0.02–0.20 mg/mL.

Keywords

ion associate extraction spectrophotometry determination of diphenhydramine extraction molybdenum(VI) galleon 

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References

  1. 1.
    Pilipenko, A.T. and Tananaiko, M.M., Raznoligandnye kompleksy i ikh primenenie v analiticheskoi khimii (Mixed-Ligand Complexes and Their Application in Analytical Chemistry), Moscow: Khimiya, 1988.Google Scholar
  2. 2.
    Mirzaeva, Kh.A., Akhmedova, M.S., and Akhmedov, S.A., Izv. Vyssh. Uchebn. Zaved., Sev.-Kavk. Reg., Estestv. Nauki, 2010, no. 4, p.71.Google Scholar
  3. 3.
    Mirzaeva, Kh.A., Akhmedov, S.A., and Babuev, M.A., Vestn. Dagestan. Nauchn. Tsentra, 2011, no. 40, p.20.Google Scholar
  4. 4.
    Mirzaeva, Kh.A., Byurnieva, U.G., Ramazanov, A.Sh., and Kimpaeva, M.M., Farmatsiya, 2012, no. 4, p.18.Google Scholar
  5. 5.
    Ivanov, V.M., Adamova, E.M., and Figurovskaya, V.N., J. Anal. Chem., 2010, vol. 65, no. 9, p.912.CrossRefGoogle Scholar
  6. 6.
    Nazarenko, V.A. and Antonovich, V.P., Trioksifluorony (Trioxyfluorones), Moscow: Nauka, 1973.Google Scholar
  7. 7.
    Bulatov, M.I. and Kalinkin, I.P., Prakticheskoe rukovodstvo po fotometricheskim metodam analiza (Practical Guidance on Photometric Methods of Analysis), Leningrad: Khimiya, 1986.Google Scholar
  8. 8.
    Antonovich, V.P., Ibragimov, G.I., Grekova, I.M., and Nazarenko, V.A., Zh. Anal. Khim., 1977, vol. 12, no. 5, p.876.Google Scholar
  9. 9.
    Mokhosoev, M.V. and Shevtsova, N.A., Sostoyanie ionov molibdena i vol’frama v vodnykh rastvorakh (State of Molybdenum and Tungsten Ions in Aqueous Solutions), Ulan-Ude: Buryatskoe Knizhn. Izd., 1977.Google Scholar
  10. 10.
    Melen’t’eva, G.A. and Antonova, L.A., Farmatsevticheskaya khimiya (Pharmaceutical Chemistry), Moscow: Meditsina, 1993.Google Scholar
  11. 11.
    Gosudarstvennaya farmakopeya RF (Russian State Pharmacopoeia), Moscow, 2008, 12th ed.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  1. 1.Faculty of ChemistryDagestan State UniversityMakhachkalaRussia
  2. 2.Dagestan State Medical UniversityMakhachkalaRussia

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