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Journal of Analytical Chemistry

, Volume 71, Issue 5, pp 519–526 | Cite as

Determination of ceftriaxone by the fluorescence quenching of quantum dots using binding with polyethyleneimine

  • V. M. Karpov
  • D. V. Spektor
  • M. K. BeklemishevEmail author
Articles

Abstract

It is found that antibiotic ceftriaxone reacts with polyethyleneimine in aqueous solutions, probably, with the formation of a noncovalent molecular complex (complex I). The product of hydrolysis of complex I, when heated in an aqueous solution (product II), quenches the fluorescence of CdSe/CdS/ZnS coreshell- shell quantum dots, probably, because of the formation of free thiol groups. A possibility of ceftriaxone determination in aqueous solutions is demonstrated. The performance characteristics of the procedure using a spectrofluorimeter and a photocamera combined with a UV light-emitting diode are close to each other (cmin = 1 × 10–6 M, RSD = 10%). Na+, Ca2+, glucose, urea, uric acid, erythromycin, ciprofloxacin, and doxycycline produce no analytical signals under the conditions of ceftriaxone determination.

Keywords

ceftriaxone polyethyleneimine molecular complex fluorescence quenching quantum dots 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • V. M. Karpov
    • 1
  • D. V. Spektor
    • 1
  • M. K. Beklemishev
    • 1
    Email author
  1. 1.Department of ChemistryMoscow State UniversityMoscowRussia

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