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Voltammetric determination of copper with proton pump inhibitor drug omeprazole

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Abstract

The electrochemical behavior of copper(II)-omeprazole complex was studied by differential pulse and cyclic voltammetry at a hanging mercury drop electrode. A well-defined voltammetric peak was obtained at −0.6 V (vs. Ag/AgCl sat’d KCl) in phosphate buffer (pH 7). The experimental results show that the reduction of the copper(II)-omeprazole complex is irreversible. The stoichiometry and stability constant of the Cu(II)-omeprazole complex were evaluated using differential pulse cathodic adsorptive stripping voltammetry and found to be 1 : 2 and 1.39 × 1011 M−1. The limits of detection and quantitation were found to be 3 × 10−9 and 1 × 10−8 M, respectively. The proposed procedure was successfully applied for the determination of trace level of copper in bottled natural drinking water samples.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt

    M. A. Ghandour & A. Hassan

  2. Forensic Chemistry Department, Forensic Medicine Authority, Cairo, Egypt

    H. M. Ali

Authors
  1. M. A. Ghandour
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  2. A. Hassan
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  3. H. M. Ali
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Correspondence to M. A. Ghandour.

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Ghandour, M.A., Hassan, A. & Ali, H.M. Voltammetric determination of copper with proton pump inhibitor drug omeprazole. J Anal Chem 70, 392–397 (2015). https://doi.org/10.1134/S1061934815030065

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  • DOI: https://doi.org/10.1134/S1061934815030065

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