Advertisement

Journal of Analytical Chemistry

, Volume 70, Issue 2, pp 240–248 | Cite as

Identification and analytical properties of acetyl fentanyl metabolites

  • A. B. Melent’ev
  • S. S. Kataev
  • O. N. Dvorskaya
Articles

Abstract

Acetyl fentanyl is a novel designer drug substance, a derivative of fentanyl. Its major metabolites were identified in samples of urine from consumers of acetyl fentanyl using gas chromatography and high-performance liquid chromatography with mass spectrometry detection. Structures of metabolites were proposed and confirmed by their fragmentation on electron impact and atmospheric pressure chemical ionization. The mass spectral and chromatographic properties of some derivatives of acetyl fentanyl metabolites were determined. The main path of the biotransformation of acetyl fentanyl is the hydroxylation of the phenylethyl moiety in the molecule.

Keywords

designer drugs acetyl fentanyl metabolism gas chromatography HPLC mass spectrometry detection 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Higashikawa, Y. and Suzuki, S., Forensic Toxicol., 2008, vol. 26, p. 1.CrossRefGoogle Scholar
  2. 2.
    Goromaru, T., Matsuura, H., Yoshimura, N., Miyawaki, T., Sameshima, T., Miyao, J., Furuta, T., and Baba, S., Anesthesiol., 1984, vol. 61, p. 73.CrossRefGoogle Scholar
  3. 3.
    Moffat, A.C., Osselton, A.D., and Widdop, B., Clarkes`s Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Postmortem Material, London: Pharmaceutical, 2011.Google Scholar
  4. 4.
    Sato, S., Suzuki, S., Lee, X.P., and Sato, K., Forensic Sci. Int., 2010, vol. 195, p. 68.CrossRefGoogle Scholar
  5. 5.
    Strano-Rossi, S., Alvarez, I., Tabernero, M.J., Cabarcos, P., Fernandez, P., and Bermejo, A.M., J. Appl. Toxicol., 2011, vol. 31, p. 649.CrossRefGoogle Scholar
  6. 6.
    Ohta, H. and Suzuki, S., J. Anal. Toxicol., 1999, vol. 23, p. 280.CrossRefGoogle Scholar
  7. 7.
    Luire, I.S. and IiO, R., J. Chromatogr. A, 2009, vol. 1216, p. 515.Google Scholar
  8. 8.
    Wichitnithad, W., McManus, T.J., and Callery, P.S., Rapid Commum. Mass Spectrom., 2010, vol. 24, p. 2547.CrossRefGoogle Scholar
  9. 9.
    Guitton, J., Desage, M., Alamercery, S., Dutruch, L., Dautraix, S., Perdrix, J.P., and Brazier, J.L., J. Chromatogr. B, 1997, vol. 59, p. 59.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • A. B. Melent’ev
    • 1
  • S. S. Kataev
    • 2
  • O. N. Dvorskaya
    • 3
  1. 1.Chelyabinsk Regional Bureau of Forensic Medical ExaminationChelyabinskRussia
  2. 2.Perm Regional Bureau of Forensic Medical ExaminationPermRussia
  3. 3.Chair of Toxicological Chemistry, Perm State Pharmaceutical AcademyMinistry for Healthcre of the Russian FederationPermRussia

Personalised recommendations