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Determination of the average molecular weight of hydroxyethyl starches by diffusion-ordered NMR spectroscopy

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Abstract

A correlation equation is obtained for the evaluation of the average molecular weight (MW) of hydroxyethyl starches from the self-diffusion coefficient D measured using diffusion-ordered NMR spectroscopy. Correlation equations MW = cD −α are compared for hydroxyethyl starches, dextrans, and pullulans. It has been demonstrated that different MWs correspond to constant D values of uncharged polysaccharides with the similar type of nonvalent interactions and different degrees of branching.

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Authors and Affiliations

  1. Scientific Center for Expertise of Medical Products, Ministry of Health of the Russian Federation, Petrovskii bul’var 8, Moscow, 127051, Russia

    N. E. Kuz’mina, S. V. Moiseev, V. I. Krylov, V. A. Yashkir & V. A. Merkulov

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  1. N. E. Kuz’mina
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  2. S. V. Moiseev
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  3. V. I. Krylov
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  4. V. A. Yashkir
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  5. V. A. Merkulov
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Correspondence to S. V. Moiseev.

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Original Russian Text © N.E. Kuz’mina, S.V. Moiseev, V.I. Krylov, V.A. Yashkir, V.A. Merkulov, 2015, published in Zhurnal Analiticheskoi Khimii, 2015, Vol. 70, No. 1, pp. 30–36.

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Kuz’mina, N.E., Moiseev, S.V., Krylov, V.I. et al. Determination of the average molecular weight of hydroxyethyl starches by diffusion-ordered NMR spectroscopy. J Anal Chem 70, 32–38 (2015). https://doi.org/10.1134/S1061934815010086

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