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Determination of fluoxetine in pharmaceutical preparations and biological samples using potentiometric sensors based on polymeric membranes

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Abstract

The construction and general performance of four novel potentiometric membrane sensors for the determination of fluoxetine have been described. The sensors are based on the formation of the ion association complex of fluoxetine with sodium tetraphenylborate and phosphotungstic acid as electroactive materialles, dispersed in a PVC matrix with dibuthyl sebacate (or diethyl sebacate) as a plasticizer. These sensors exhibit fast, stable and near-Nernstian response for the monocharged fluoxetine cation over wide concentration range from 3.0 × 10−6 to 1.2 × 10−2 M and pH 4.0–7.5. No interferences are caused by many inorganic and organic species. Direct potentiometric determinations of 5–100 μg/mL of fluoxetine in drug and urine samples show good recovery of fluoxetine. The developed membrane electrodes have been used as an end point indicator electrode; the potentiometric titration of fluoxetine with sodium tetraphenylborate as a titrant has been monitored.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Guilan, Rasht, P.O. Box 1914, Iran

    M. Arvand

  2. Environmental Research Institute, University of Applied Science and Technology, Rasht, P.O. Box 41635-3114, Iran

    N. Ahmadi Rad

Authors
  1. M. Arvand
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  2. N. Ahmadi Rad
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Arvand, M., Ahmadi Rad, N. Determination of fluoxetine in pharmaceutical preparations and biological samples using potentiometric sensors based on polymeric membranes. J Anal Chem 68, 183–188 (2013). https://doi.org/10.1134/S1061934813020020

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  • DOI: https://doi.org/10.1134/S1061934813020020

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