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A new sensor for electrochemical determination of captopril using chlorpromazine as a mediator at a glassy carbon electrode

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Abstract

A new simple, selective and rapid cyclic voltammetric method is reported for the accurate and precise determination of captopril using chlorpromazine as a suitable electrocatalyst. It has been shown by cyclic voltammetry, single step chronoamperometry and electrochemical impedance spectroscopy that chlorpromazine can catalyze the oxidation of captopril in aqueous buffer solution and produces a sharp oxidation peak current at about 0.625 V vs. saturated calomel reference electrode. The catalytic oxidation peak current of captopril is linearly dependent on its concentration and enables the determination of captopril over the concentration range of 8–1000 μM at pH 5.0, with a detection limit of 4.8 μM. The relative standard deviation for the determination of 400 μM captopril is 0.66% (n = 9). The influence of potential interfering substances on the determination of captopril was studied. The method was satisfactorily applied to the determination of captopril in real samples such as drug and urine.

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References

  1. Cushman, D.W., Cheung, H.S., Sabo, E.F., and Ondetti, M.A., in Angiotensin Converting Enzyme Inhibitors, Horowitz, Z.P., Ed., Munich: Urban and Schwarzenberg, 1981, p. 3.

    Google Scholar 

  2. Tse, H.F., Ng, W., Chan, K.K., Li, S.K., Keung, K.K., Lau, Y.K., Chen, W.H., Tang, Y.W., and Leung, S.K., Am. J. Cardiol., 2002, vol. 89, p. 150.

    Article  Google Scholar 

  3. Joly, D., Rieu, P., Mejean, A., Gagnadoux, M.F., Daudon, M., and Jungers, P., Pediatr. Nephrol., 1999, vol. 13, p. 945.

    Article  CAS  Google Scholar 

  4. Sloand, J.A. and Izzo, J.L., Arch. Intern. Med., 1987, vol. 147, p. 1409.

    Article  CAS  Google Scholar 

  5. Perazella, M. and Buller, G.K., Am. J. Kidney Dis., 1993, vol. 21, p. 504.

    CAS  Google Scholar 

  6. de Cavanagh, E.M.V., Inserra, F., Felder, L., Romano, L., Ercole, L., and Fraga, C.G., FEBS Letters, 1995, vol. 361, p. 22.

    Article  Google Scholar 

  7. Golik, A., Modai, D., Averbukh, D., Sheffy, M., Shamis, A., Cohen, N., Shaked, U., and Dolev, E., Metabolism, 1990, vol. 39, p. 665.

    Article  CAS  Google Scholar 

  8. Golik, A., Zaidenstein, R., Dishi, V., Blatt, A., Cohen, N., Cotter, G., Berman, S., and Weissgarten, J., J. Am. Coll. Nutr., 1998, vol. 17, p. 75.

    CAS  Google Scholar 

  9. Kelly, J.G. and O’Malley, K., Clin. Pharmacokinet., 1990, vol. 19, p. 177.

    Article  CAS  Google Scholar 

  10. Good, C.B., McDermott, L., and McCloskey, B., J. Am. Med. Assoc., 1995, vol. 274, p. 538.

    Article  CAS  Google Scholar 

  11. Rush, J.E. and Merrill, D.D., J. Cardiovasc. Pharmacol., 1987, vol. 9, p. 99.

    Article  Google Scholar 

  12. Physician’s Desk Reference, Sifton, D.W., Ed., Montvale, NJ: Medical Economics Company, 2000.

    Google Scholar 

  13. Favaro, G. and Fiorani, M., Anal. Chim. Acta, 1996, vol. 332, p. 249.

    Article  CAS  Google Scholar 

  14. Kus’mierek, K. and Bald, E., Chromatographia, 2007, vol. 66, p. 71.

    Article  Google Scholar 

  15. Kok, R.J., Visser, J., Moolenaar, F., de Zeeuw, D., and Meijer, D.K.F., J. Chromatogr., B, 1997, vol. 693, p. 181.

    Article  CAS  Google Scholar 

  16. Hillaert, S., and van den Bossche, W., J. Pharm. Biomed. Anal., 1999, vol. 21, p. 65.

    Article  CAS  Google Scholar 

  17. Perez-Ruiz, T., Martinez-Lozano, C., and Galera, R., Electrophoresis, 2006, vol. 27, p. 2310.

    Article  CAS  Google Scholar 

  18. Rahman, N., Singh, M., and Hoda, M.N., Il Farmaco, 2005, vol. 60, p. 569.

    Article  CAS  Google Scholar 

  19. Jankowski, A., Skorek, A., Krzys’ko, K., Zarzycki, P.K., Ochocka, R.J., and Lamparczyk, H., J. Pharm. Biomed. Anal., 1995, vol. 13, p. 655.

    Article  CAS  Google Scholar 

  20. Amini, M., Zarghi, A., and Vatanpour, H., Pharm. Acta Helvetiae, 1999, vol. 73, p. 303.

    Article  CAS  Google Scholar 

  21. Huang, T., He, Z., Yang, B., Shao, L., Zheng, X., and Duan, G., J. Pharm. Biomed. Anal., 2006, vol. 41, p. 644.

    Article  CAS  Google Scholar 

  22. Sypniewski, S. and Bald, E., J. Chromatogr., A, 1996, vol. 729, p. 335.

    Article  CAS  Google Scholar 

  23. Al-Ghannam, S.M., El-Brashy, A.M., and Al-Farhan, B.S., Il Farmaco, 2002, vol. 57, p. 625.

    Article  CAS  Google Scholar 

  24. Song, Z., Hou, S., Yu, X., Xie, X., and Shao, X., Anal. Lett., 2006, vol. 39, p. 1115.

    Article  CAS  Google Scholar 

  25. Salem, I.I., Saif, W.A., Jmeian, Y., and Al Tamimi, J.I., J. Pharm. Biomed. Anal., 2005, vol. 37, p. 1073.

    Article  CAS  Google Scholar 

  26. Ensafi, A.A. and Hajian, R., J. Braz. Chem. Soc., 2008, vol. 19, p. 405.

    Article  CAS  Google Scholar 

  27. Ioannides, X., Economou, A., and Voulgaropoulos, A., J. Pharm. Biomed. Anal., 2003, vol. 33, p. 309.

    Article  CAS  Google Scholar 

  28. Karimi-Maleh, H., Ensafi, A.A., and Allafchian, A.R., J. Solid State Electrochem., 2010, vol. 14, p. 9.

    Article  CAS  Google Scholar 

  29. Hayen, H. and Karst, U., Anal. Chem., 2003, vol. 75, p. 4833.

    Article  CAS  Google Scholar 

  30. Takamura, K., Inoue, S., Kusu, F., Otagiri, M., and Uekama, K., Chem. Pharm. Bull., 1983, vol. 31, p. 1821.

    Article  CAS  Google Scholar 

  31. Mielech-Lukasiewicz, K., Puzanowska-Tarasiewicz, H., and Panuszko, A., Anal. Lett., 2008, vol. 41, p. 789.

    Article  CAS  Google Scholar 

  32. Blankert, B., Hayen, H., van Leeuwen, S.M., Karst, U., Bodoki, E., Lotrean, S., Sandulescu, R., Mora Diez, N., Dominguez, O., Arcos, J., and Kauffmann, J.M., Electroanalysis, 2005, vol. 17, p. 1501.

    Article  CAS  Google Scholar 

  33. Galus, Z., Fundumentals of Electrochemical Analysis, New York: Ellis Horwood, 1976.

    Google Scholar 

  34. Mirmomtaz, E., Ensafi, A.A., and Karimi-Maleh, H., Electroanalysis, 2008, vol. 20, p. 1973.

    Article  CAS  Google Scholar 

  35. Beitollahi, H., Karimi-Maleh, H., and Khabazzadeh, H., Anal. Chem., 2008, vol. 80, p. 9499.

    Article  Google Scholar 

  36. User Manual for Software FRA 4.9 (Autolab System), Netherlands: Eco Chemie, 2007.

  37. Maritan, A. and Toigo, F., Electrochim. Acta, 1990, vol. 35, p. 141.

    Article  CAS  Google Scholar 

  38. Bard, A.J. and Faulkner, L.R., Electrochemical Methods: Fundamentals and Applications, New York: Wiley, 2001.

    Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran

    Ali A. Ensafi & A. Arabzadeh

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  1. Ali A. Ensafi
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  2. A. Arabzadeh
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Ensafi, A.A., Arabzadeh, A. A new sensor for electrochemical determination of captopril using chlorpromazine as a mediator at a glassy carbon electrode. J Anal Chem 67, 486–496 (2012). https://doi.org/10.1134/S1061934812050024

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