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Journal of Analytical Chemistry

, Volume 66, Issue 14, pp 1437–1440 | Cite as

Complexation of antibiotic levomycetin (Chloroamphenicol) with α-hederin and hederasaponin c under the conditions of electrospray ionization

  • A. V. Lekar’
  • L. A. Yakovishin
  • S. N. Borisenko
  • E. V. Vetrova
  • N. I. BorisenkoEmail author
Articles

Abstract

The complexation of antibiotic levomycetin (chloroamphenicol) with triterpene glycoside α-hederin and hederasaponin C was investigated by electrospray ionization mass spectrometry. The glycosides form complexes with levomycetin in the molar ratio 1: 1. The molecular complex of α-hederin is more stable than the one of hederasaponin C because of the presence of a free carboxyl group in its aglycone fragment. The carboxyl group of hederasaponin C is involved into the formation of a glycosidic bond with the trisaccharide unit and is not available for complex formation.

Keywords

electrospray ionization mass spectrometry triterpene glycoside α-hederin hederasaponin C levomycetin molecular complex 

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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • A. V. Lekar’
    • 1
  • L. A. Yakovishin
    • 2
  • S. N. Borisenko
    • 1
  • E. V. Vetrova
    • 1
  • N. I. Borisenko
    • 3
    Email author
  1. 1.Research Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-DonRussia
  2. 2.Chair of Physics (Course of Chemistry)Sevastopol National Technical UniversitySevastopolUkraine
  3. 3.Center of Analytics and EcologySouthern Federal UniversityRostov-on-DonRussia

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