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Complexation of antibiotic levomycetin (Chloroamphenicol) with α-hederin and hederasaponin c under the conditions of electrospray ionization

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Abstract

The complexation of antibiotic levomycetin (chloroamphenicol) with triterpene glycoside α-hederin and hederasaponin C was investigated by electrospray ionization mass spectrometry. The glycosides form complexes with levomycetin in the molar ratio 1: 1. The molecular complex of α-hederin is more stable than the one of hederasaponin C because of the presence of a free carboxyl group in its aglycone fragment. The carboxyl group of hederasaponin C is involved into the formation of a glycosidic bond with the trisaccharide unit and is not available for complex formation.

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Authors and Affiliations

  1. Research Institute of Physical and Organic Chemistry, Southern Federal University, pr. Stachki 194/2, Rostov-on-Don, 344090, Russia

    A. V. Lekar’, S. N. Borisenko & E. V. Vetrova

  2. Chair of Physics (Course of Chemistry), Sevastopol National Technical University, ul. Universitetskaya 33, Sevastopol, 99053, Ukraine

    L. A. Yakovishin

  3. Center of Analytics and Ecology, Southern Federal University, ul. Zorge 7, Rostov-on-Don, 344090, Russia

    N. I. Borisenko

Authors
  1. A. V. Lekar’
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  2. L. A. Yakovishin
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  3. S. N. Borisenko
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  4. E. V. Vetrova
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  5. N. I. Borisenko
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Corresponding author

Correspondence to N. I. Borisenko.

Additional information

Original Russian Text © A.V. Lekar’, L.A. Yakovishin, S.N. Borisenko, E.V. Vetrova, N.I. Borisenko, 2011, published in Mass-spektrometria, 2011, 8(2), pp. 111–114.

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Lekar’, A.V., Yakovishin, L.A., Borisenko, S.N. et al. Complexation of antibiotic levomycetin (Chloroamphenicol) with α-hederin and hederasaponin c under the conditions of electrospray ionization. J Anal Chem 66, 1437–1440 (2011). https://doi.org/10.1134/S1061934811140115

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  • DOI: https://doi.org/10.1134/S1061934811140115

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