Voltammetric determination of nitrendipine on composite film modified electrode
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This paper was focused on the use of electrochemical methods based on a novel composite film modified electrode for the pharmaceutical analysis. This modified electrode was fabricated by integration of room-temperature ionic liquids (1-butyl-3-methylimidazolium hexafluophosphate) and multi-walled carbon nanotubes with polymeric matrix (chitosan). This sensor showed good stability and high accumulation efficiency. Electrochemical behavior of nitrendipine at this electrode was investigated in detail. A sensitive cathodic peak was observed at −0.76 V on the modified electrode. Under the optimized conditions, the peak current was linear to nitrendipine concentration in the range of 4.0 × 10−7 ∼ 5.0 × 10−5 M, and the detection limit was estimated to be 1.0 × 10−7 M after an accumulation for 150 s on open circuit. In addition, the proposed method was applied to the determination of nitrendipine in real samples, and the recovery was from 97.6 to 102.5%.
Keywordsvoltammetric determination nitrendipine
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