Voltammetric determination of nitrendipine on composite film modified electrode

  • Yingliang Wei
  • Lan Zhang
  • Luping Zhang
  • Chen Shao
  • Chao Li


This paper was focused on the use of electrochemical methods based on a novel composite film modified electrode for the pharmaceutical analysis. This modified electrode was fabricated by integration of room-temperature ionic liquids (1-butyl-3-methylimidazolium hexafluophosphate) and multi-walled carbon nanotubes with polymeric matrix (chitosan). This sensor showed good stability and high accumulation efficiency. Electrochemical behavior of nitrendipine at this electrode was investigated in detail. A sensitive cathodic peak was observed at −0.76 V on the modified electrode. Under the optimized conditions, the peak current was linear to nitrendipine concentration in the range of 4.0 × 10−7 ∼ 5.0 × 10−5 M, and the detection limit was estimated to be 1.0 × 10−7 M after an accumulation for 150 s on open circuit. In addition, the proposed method was applied to the determination of nitrendipine in real samples, and the recovery was from 97.6 to 102.5%.


voltammetric determination nitrendipine 


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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • Yingliang Wei
    • 1
  • Lan Zhang
    • 1
  • Luping Zhang
    • 2
  • Chen Shao
    • 2
  • Chao Li
    • 2
  1. 1.Department of Environment Engineering and ChemistryLuoyang Institute of Science and TechnologyLuoyangP.R. China
  2. 2.Department of Material and Chemical EngineeringZhengzhou University of Light IndustryZhengzhouP.R. China

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