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Methodology of the spectrophotometric analysis of organic mixtures: Application of statistical models

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Abstract

Deviations of the absorbance of mixtures from additivity can be detected and predicted using statistical models obtained in the complete factorial experiment. The models correlate the deviations with the composition of a mixture; this allows the optimization of the procedures of spectrophotometric analysis. The advantages and limitations of this approach are demonstrated on an example of the analysis of pharmaceutical preparations and antioxidant mixtures.

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Authors and Affiliations

  1. Dostoevsky Omsk State University, pr. Mira 55A, Omsk, 644077, Russia

    V. I. Vershinin, I. V. Vlasova & M. A. Khar’kova

  2. Kuban State University, Stavropol’skaya ul. 149, Krasnodar, 350040, Russia

    T. G. Tsypko & N. A. Nikolaeva

Authors
  1. V. I. Vershinin
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  2. I. V. Vlasova
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  3. T. G. Tsypko
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  4. N. A. Nikolaeva
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  5. M. A. Khar’kova
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Additional information

Original Russian Text © V.I. Vershinin, I.V. Vlasova, T.G. Tsypko, N.A. Nikolaeva, M.A. Khar’kova, 2011, published in Zhurnal Analiticheskoi Khimii, 2011, Vol. 66, No. 7, pp. 708–715.

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Vershinin, V.I., Vlasova, I.V., Tsypko, T.G. et al. Methodology of the spectrophotometric analysis of organic mixtures: Application of statistical models. J Anal Chem 66, 595–602 (2011). https://doi.org/10.1134/S106193481107015X

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  • DOI: https://doi.org/10.1134/S106193481107015X

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