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Development of spectrofluorimetric methods for the determination of levosulpiride in pharmaceutical formulation

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Abstract

Simple, accurate, rapid, and sensitive spectrofluorimetric methods for the determination of levosulpiride in pharmaceutical formulation were developed utilizing its fluorescence reaction with Fe3+ (method A) and Al3+ (method B). The calibration curves were found to be linear in the concentration range 0.239–3.44 μg/mL and 0.310–2.730 μg/mL with limit of detection 0.005 μg/mL and 0.0032 μg/mL, respectively, for method A and method B. The reaction conditions were studied and optimized. In addition, the complexation of Mg2+ and Ca2+ was also studied. In all cases, an enhancement in fluorescence emission of levosulpiride upon formation of complex with metal ions was observed. A 2: 1 (drug: metal) stoichiometry for all the complexes was established. Benesi-Hildebrand method was applied for calculation of association constant at 25 and 35°C. The thermodynamic parameters obtained in this study revealed that the interaction process was spontaneous and mainly ΔS-driven.

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Authors and Affiliations

  1. Department of Chemistry, Aligarh Muslim University, Aligarh, 202001, India

    Shaista Bano, Ayaz Mohd, Aftab Aslam Parwaz Khan & K. S. Siddiqi

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  1. Shaista Bano
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  2. Ayaz Mohd
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  3. Aftab Aslam Parwaz Khan
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  4. K. S. Siddiqi
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Bano, S., Mohd, A., Khan, A.A.P. et al. Development of spectrofluorimetric methods for the determination of levosulpiride in pharmaceutical formulation. J Anal Chem 66, 603–609 (2011). https://doi.org/10.1134/S1061934811070124

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  • DOI: https://doi.org/10.1134/S1061934811070124

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