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Journal of Analytical Chemistry

, Volume 65, Issue 13, pp 1341–1346 | Cite as

Analyssis of pharmaceutical substances by reaction gas chromatography/mass spectrometry

  • I. V. GulyaevEmail author
  • A. I. Revel’skii
Articles

Abstract

Derivatization of six pharmaceutical substances (catopril, metoclopramide, sotalol, hydrochlorothiazide, nalidixic acid, and stavudine) has been performed using five derivatizing reagents of different types; the derivatization has been followed by the GC/MS detection of the resultant products. The number of labile hydrogen atoms in the initial molecules substituted by the structural fragments of derivatizing reagents has been determined.

Keywords

pharmaceutical substances impurities derivatization GC/MS pharmaceuticals 

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Department of ChemistryMoscow State UniversityMoscowRussia

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