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Using dextromethorphan potentiometric membrane sensor in analysis of dextromethorphan hydrobromide in pharmaceutical formulation and urine; Computational study

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Abstract

Dextromethorphan (DXM) is an antitussive (cough Hyj/UA suppressant) drug found in many cough medicines. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychoactive applications. In this study, a potentiometric liquid membrane sensor for simple and fast determination of dextromethorphan hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, DXM-tetraphenylborate complexes were employed as electroactive materials in the membrane. The wide linear range (10−6–10−2 M), low detection limit (1 × 10−6 M), and fast response time (∼5 s) characterize the proposed sensors. Validation of the method shows suitability of the sensors for applications in the determination of dextromethorphan hydrobromide in pharmaceutical formulation and urine.

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Authors and Affiliations

  1. Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran

    M. R. Ganjali, S. Riahi & P. Norouzi

  2. Endocrinology & Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran

    M. R. Ganjali, B. Larijani, F. Faridbod & P. Norouzi

  3. Department of Chemistry, Islamic Azad University of Shahreray Branch, Shahreray, Iran

    H. Shams

  4. Institute of Petroleum Engineering, Faculty of Engineering, University of Tehran, Tehran, Iran

    S. Riahi

Authors
  1. M. R. Ganjali
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  2. B. Larijani
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  3. H. Shams
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  4. S. Riahi
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  5. F. Faridbod
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  6. P. Norouzi
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Ganjali, M.R., Larijani, B., Shams, H. et al. Using dextromethorphan potentiometric membrane sensor in analysis of dextromethorphan hydrobromide in pharmaceutical formulation and urine; Computational study. J Anal Chem 65, 1052–1060 (2010). https://doi.org/10.1134/S1061934810100114

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  • DOI: https://doi.org/10.1134/S1061934810100114

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