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Journal of Analytical Chemistry

, Volume 65, Issue 6, pp 608–613 | Cite as

Design of a peptide linker group to increase the surface enhanced Raman spectroscopy signal intensity of a rhodamine-nanoparticle system

  • Philip Drake
  • Hsiang-Yuan Huang
  • Yuh-Jiuan Lin
Articles

Abstract

The surface enhanced resonance Raman spectra of three modified carboxy-x-rhodamine dyes were recorded using Au nanoparticles and an excitation laser operating at 670 nm. The dyes were modified with a linker group designed both to increase the surface enhanced Raman spectroscopy signal and to couple the dye to the Au nanoparticles surface. The maximum signal intensity was recorded for a Cys-Gly linker with Cys thiol group acting as the coupling point to the Au surface and Gly-NH2 group used to attach the carboxy-x-rhodamine dye. This gave a signal intensity in the 1503 cm−1 Raman peak that was more than 20 times greater than for the unmodified dye. The Au nanoparticles used had a diameter of 49.8 ± 1.2 nm and were synthesised by the citrate reduction method.

Keywords

Surface Enhance Raman Spectroscopy Fmoc Linker Group Surface Enhance Raman Spectroscopy AuNP Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • Philip Drake
    • 1
  • Hsiang-Yuan Huang
    • 1
  • Yuh-Jiuan Lin
    • 1
  1. 1.Medical Electronics and Device Technology CentreIndustrial Technology Research InstituteHsinchuTaiwan

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