Journal of Analytical Chemistry

, Volume 65, Issue 3, pp 260–266 | Cite as

Fluorescence sensor for nitrofurazone using 4-methyl-7-allyloxynaphtho[1,2-b]pyran-2-ketone as sensing carrier

  • Lixin Chen
  • Chenggang Niu
  • Zhimin Xie
  • Nianyuan Tan


4-methyl-7-allyloxynaphtho[1,2-b]pyran-2-ketone (MANPK), a naphthopyran derivative, was synthesized as a fluorescent carrier for the preparation of an optical chemical sensor for nitrofurazone. To prevent the leakage of the fluorophore, MANPK with a terminal double bond was photo-copolymerized with 2-hydroxypropyl methacrylate on the silanized glass surface. The response of the sensor is based on fluorescence quenching of MANPK by nitrofurazone. The sensor shows sufficient reproducibility, selectivity and a long lifetime. Nitrofurazone can be determined in the range from 6.0 × 10−6 to 8.0 × 10−4 M with a detection limit of 4.5 × 10−6 M at pH 6.0. The sensor has been applied to the direct determination of nitrofurazone in pharmaceutical preparations and urine samples.


Pyran Fluorescence Sensor Anhydrous Potassium Carbonate Terminal Double Bond Nitrofurazone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • Lixin Chen
    • 1
  • Chenggang Niu
    • 2
  • Zhimin Xie
    • 1
  • Nianyuan Tan
    • 1
  1. 1.Department of Chemistry and Chemical EngineeringHunan institute of engineeringXiangtanP. R. China
  2. 2.Department of Environmental Science and EngineeringHunan UniversityChangshaP. R. China

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