Electrocatalytic determination of dopamine in pharmaceutical and human serum samples by using [N,N′-bis(2-pyridine carboxamido)-1,2-benzene] nickel(II) modified carbon paste electrode
The main purpose of this study is to develop an inexpensive, simple, selective and especially sensitive modified carbon paste electrode (MCPE) for the determination of dopamine (DA) in pharmaceutical and human serum samples. The carbon paste electrode (CPE) has been modified by using [N,N′-bis(2-pyridine carboxamido)-1,2-benzene] nickel(II) complex (Ni(II)bpb) and the electrochemical behavior of the modified electrode has been studied by cyclic voltammetry. The modified electrode shows an excellent electrocatalytic effect on the oxidation of DA. Under optimum conditions, calibration plots are found to be linear in the range of 7.0 × 10−7−1.0 × 10−5 M (r2 = 0.9940) and 1.0 × 10−5−1.0 × 10−4 M (r2 = 0.9945); the detection limit is 6.2 × 10−8 M. The preparation of MCPE is very easy. The electrode can be renewed by simple polishing. The proposed method shows good sensitivity, reproducibility (RSD ∼ 2.9%), high stability (more than two month) without any considerable change in response and recovery for the determination of DA. The prepared electrode has been successfully applied to the voltammetric determination of DA in pharmaceutical and biological samples.
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