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Determination of parabens in pharmaceutical and cosmetic products by capillary electrophoresis


A validated capillary electrophoresis method for the determination of parabens-methyl, ethyl, propyl, and butyl is described. The optimum results were obtained by the use of a run buffer containing 20 mM borate buffer (pH 9.0) with 10% methanol and by applying a voltage of 20 kV, a low hydrodynamic injection of 10 s, and detecting the signals at 200 nm. Moxifloxazin was used as an internal standard. All parabens were separated within 10 min. The method showed a good repeatability, linearity, and sensitivity. It was applied to the determination of parabens in pharmaceutical and certain cosmetic products.

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Correspondence to U. D. Uysal.

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Uysal, U.D., Güray, T. Determination of parabens in pharmaceutical and cosmetic products by capillary electrophoresis. J Anal Chem 63, 982–986 (2008).

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