Skip to main content
SpringerLink
Log in

Determination of parabens in pharmaceutical and cosmetic products by capillary electrophoresis

Journal of Analytical Chemistry volume 63, pages 982–986 (2008)Cite this article

Abstract

A validated capillary electrophoresis method for the determination of parabens-methyl, ethyl, propyl, and butyl is described. The optimum results were obtained by the use of a run buffer containing 20 mM borate buffer (pH 9.0) with 10% methanol and by applying a voltage of 20 kV, a low hydrodynamic injection of 10 s, and detecting the signals at 200 nm. Moxifloxazin was used as an internal standard. All parabens were separated within 10 min. The method showed a good repeatability, linearity, and sensitivity. It was applied to the determination of parabens in pharmaceutical and certain cosmetic products.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

References

  1. Bredin, J., Davin-Regli, A., and Page’s, J.M., J. Antimicr. Chemother., 2005, vol. 55, p. 1013.

    Article  CAS  Google Scholar 

  2. Passone, M.A., Resnik, S.L., and Etcheverry, M.G., J. Appl. Microbiology, 2005, vol. 99, no. 3, p. 682.

    Article  CAS  Google Scholar 

  3. Soni, M.G., Carabin, I.G., and Burdock, G.A., Food Chem. Toxicol., 2005, vol. 43, no. 7, p. 985.

    Article  CAS  Google Scholar 

  4. Soni, M.G., Taylor, S.L., Greenberg, N.A., and Burdock, G.A., Food Chem. Toxicol., 2002, vol. 40, no. 10, p. 1335.

    Article  CAS  Google Scholar 

  5. Jaworska, M., Szulinska, Z., and Wilk, M., J. Sep. Sci., 2005, vol. 28, no. 2, p. 137.

    Article  CAS  Google Scholar 

  6. Zhang, Q., Lian, M., Liu, L., and Cui, H., Anal. Chim. Acta, 2005, vol. 537, nos. 1–2, p. 31.

    Article  CAS  Google Scholar 

  7. Pugazhendhi, D., Pope, G.S., and Darbre, P.D., J. Appl. Toxicol., 2005, vol. 25, no. 4, p. 301.

    Article  CAS  Google Scholar 

  8. Golden, R., Gandy, J., and Vollmer, G., Crit. Rev. Toxicol., 2005, vol. 35, no. 5, p. 435.

    Article  CAS  Google Scholar 

  9. Garcia, I., Ortiz, M.C., Sarabia, L., Vilches, C., and Gredilla, E., J. Chromatogr. A, 2003, vol. 992, nos. 1–2, p. 11.

    Article  CAS  Google Scholar 

  10. Hajkova, R., Solich, P., Pospisilova, M., and Sicha, J., Anal. Chim. Acta, 2002, vol. 467, nos. 1–2, p. 91.

    Article  CAS  Google Scholar 

  11. Saad, B., Bari, M.F., Saleh, M.I., Ahmad, K., and Talib, M.K.M., J. Chromatogr., A, 2005, vol. 1073, nos. 1–2, p. 393.

    Article  CAS  Google Scholar 

  12. Driouich, R., Takayanagi, T., Oshima, M., and Motomizu, S., J. Chromatogr., A, 2000, vol. 903, nos. 1–2, p. 271.

    Article  CAS  Google Scholar 

  13. Baalbaki, B., Blanchin, M.D., and Fabre, H., Anal. Chim. Acta, 2002, vol. 463, no. 1, p. 15.

    Article  CAS  Google Scholar 

  14. Huang, H.Y., Lai, Y.C., Chiu, C.W., and Yeh, J.M., J. Chromatogr., A, 2003, vol. 993, nos. 1–2, p. 153.

    Article  CAS  Google Scholar 

  15. Bodor, R., Zuborova, M., Olvecka, E., Madajova, V., Masar, M., Kaniansky, D., and Stanislawski, B., J. Sep. Sci., 2001, vol. 24, no. 9, p. 802.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Science, Department of Chemistry, Anadolu University, Eskišehir, Turkey

    U. D. Uysal

  2. Faculty of Arts and Science, Department of Chemistry, Eskišehir Osmangazi University, Eskišehir, Turkey

    T. Güray

Authors
  1. U. D. Uysal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Güray
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to U. D. Uysal.

Additional information

The text was submitted by the authors in English.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Uysal, U.D., Güray, T. Determination of parabens in pharmaceutical and cosmetic products by capillary electrophoresis. J Anal Chem 63, 982–986 (2008). https://doi.org/10.1134/S1061934808100109

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1061934808100109

Keywords

search

Navigation