Journal of Analytical Chemistry

, Volume 63, Issue 1, pp 65–68 | Cite as

Some aspects of the analysis of Validol tablets by gas-liquid chromatography

  • G. B. Golubitskii
  • E. M. Basova
  • V. M. Ivanov


The possibility of using the pharmaceutical substance Validol as a reference sample instead of a model mixture of components was theoretically considered for the analysis of Validol tablets. It was shown that the maximum relative error appeared because the difference in the compositions of the reference sample and the substance used in production should not exceed 2.5%. A procedure was developed for the analysis of Validol tablets. The performance characteristics of the procedure and the accuracy of the results were determined in an analysis of model mixtures and commercial tablets.


Model Mixture Menthol Regulatory Requirement Maximum Permissible Concentration Maximum Relative Error 
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    Stolyarov, B.V., Savinov, I.M., and Vitenberg, A.G., Rukovodstvo k prakticheskim rabotam po gazovoi khromatografii (A Handbook on Practical Works in Gas Chromatorgaphy), Leningrad: Khimiya, 1988.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2008

Authors and Affiliations

  • G. B. Golubitskii
    • 1
  • E. M. Basova
    • 2
  • V. M. Ivanov
    • 3
  1. 1.OAO Pharmstandard-LeksredstvaKurskRussia
  2. 2.Dubna International University of Nature, Society and Human BeingDubna, Moscow oblastRussia
  3. 3.Department of ChemistryMoscow State UniversityVorob’evy gory, MoscowRussia

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