Skip to main content
SpringerLink
Log in

Heterocoagulation of polysaccharide-coated platinum nanoparticles with ovarian-cancer cells

  • Published:
Colloid Journal Aims and scope Submit manuscript

Abstract

Platinum nanoparticles coated with adsorption layers of polysaccharides of Chlorella vulgaris (PtPS) have been synthesized and their heterocoagulation with human ovarian-cancer cells of the A2780 line has been studied. It has been shown that the characteristic time of the aggregation of the cells with PtPS nanoparticles is 20–25 min, which corresponds to fast barrierless coagulation. The cytotoxic effect of PtPS nanoparticles reaches saturation and more than 50% of the cells die within this time period. Cytomorphological investigations have shown that A2780 cells with doubled resistance to an antitumoral antibiotic, doxorubicin, are more sensitive to the toxic action of PtPS nanoparticles than nonresistant cells are. An electrokinetic control test has been proposed for cancer-cell resistance based on the measurement of variations in the ζ-potential of nanoparticles due to adsorption of water-soluble metabolites of the cells on a particle surface.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dykman, L. and Khlebtsov, N., Chem. Soc. Rev., 2012, vol. 41, p. 2256.

    Article  CAS  Google Scholar 

  2. Dykman, L.A. and Bogatyrev, V.A., Usp. Khim., 2007, vol. 76, p. 1.

    Article  Google Scholar 

  3. Jain, P.K., Huang, X., El-Sayed, I.H., and El-Sayed, M.A., Plasmonics, 2007, vol. 2, p. 107.

    Article  CAS  Google Scholar 

  4. Vigderman, L. and Zubarev, E.R., Adv. Drug Deliv. Rev., 2012, vol. 64, p. 1.

    Google Scholar 

  5. Pissuwan, D., Niidome, T., and Cortie, M., J. Control. Release, 2011, vol. 149, p. 65.

    Article  CAS  Google Scholar 

  6. Dreaden, E.C., Alkilany, A.M., Huang, X., Murphy, C.J., and El-Sayed, M.A., Chem. Soc. Rev., 2012, vol. 41, p. 2740.

    Article  CAS  Google Scholar 

  7. Cai, W., Gao, T., Hong, H., and Sun, J., Nanotechnology, Sci. Appl., 2008, vol. 1, p. 17.

    CAS  Google Scholar 

  8. Krutyakov, Yu.A., Kudrinskii, A.A., Olenin, A.Yu., and Lisichkin, G.V., Usp. Khim., 2008, vol. 77, p. 272.

    Article  Google Scholar 

  9. Gubin, S.P., Koksharov, Yu.A., Khomutov, G.B., and Yurkov, G.Yu., Usp. Khim., 2005, vol. 74, p. 539.

    Article  Google Scholar 

  10. Rani, D., Somasundaram, V.H., Nair, S., and Koyakutty, M., J. Indian Inst. Sci., 2012, vol. 92, p. 187.

    CAS  Google Scholar 

  11. Shi, J., Xiao, Z., Kamaly, N., and Farokhzad, O.C., Acc. Chem. Res., 2011, vol. 44, p. 1123.

    Article  CAS  Google Scholar 

  12. Huang, X., Prashant, K.J., El-Sayed, I.H., and El-Sayed, M.A., Lasers Med. Sci., 2008, vol. 23, p. 217.

    Article  Google Scholar 

  13. Arvizo, R.R., Bhattacharyya, S., Kudgus, R.A., Giri, K., Bhattacharya, R., and Mukherjee, P., Chem. Soc. Rev., 2012, vol. 41, p. 2943.

    Article  CAS  Google Scholar 

  14. Yang, T., Mocofanescu, A., Shen, C., Gao, H., and Xiao, C., in Micro and Nano Manipulations for Biomedical Applications, Yih, T.C. and Talpasanu, L., Eds., Boston-London: Artech House, 2008, p. 43.

  15. Bhattacharya, R. and Mukherjee, P., Adv. Drug Deliv. Rev., 2008, vol. 60, p. 1289.

    Article  CAS  Google Scholar 

  16. Soënichsen, C., PhD Thesis (Ludwig-Maximilians-Univ., Munich, 2001).

  17. Abalde-Cela, S., Aldeanueva-Potel, P., Mateo-Mateo, C., Rodríguez-Lorenzo, L., Alvarez-Puebla, R.A., and Liz-Marzán, L.M., J. R. Soc. Interface, 2010, vol. 7, p. 435.

    Article  Google Scholar 

  18. Brusnetsov, N.A., Baiburtskii, F.S., Tarasov, V.V., Tarasov, V.V., Komissarova, L.Kh., and Filippov, V.I., Khim.-Farm. Zh., 2002, vol. 36, no. 4, p. 32.

    Google Scholar 

  19. Galanov, A.I., Yurmazova, T.A., Savel’ev, G.G., Buldakov, M.A., Rudyk, Yu.V., Letvyakov, N.V., Nechaev, K.A., Tuzikov, S.A., Cherdyntseva, N.V., and Yavorovskii, N.A., Sib. Onkol. Zh., 2008, vol. 27, no. 3, p. 50.

    Google Scholar 

  20. Ismailova, G.K., Efremenko, V.I., and Kuregyan, A.G., Khim.-Farm. Zh., 2005, vol. 39, no. 7, p. 47.

    Google Scholar 

  21. Khlebtsov, B.N., Zharov, V.P., Melnikov, A.G., Tuchin, V.V., and Khlebtsov, N.G., Nanotechnology, 2006, vol. 17, p. 5167.

    Article  CAS  Google Scholar 

  22. Alekseeva, A.V., Bogatyrev, V.A., Khlebtsov, B.N., Mel’nikov, A.G., Dykman, L.A., and Khlebtsov, N.G., Colloid J., 2006, vol. 68, p. 661.

    Article  CAS  Google Scholar 

  23. Gamaleya, N.F., Lisnyak, I.O., and Prokopenko, I.V., Fotobiol. Fotomed., 2010, vol. 7, p. 67.

    Google Scholar 

  24. Yatsimirskii, K.B., Problemy bioneorganicheskoi khimii (Problems of Bioinorganic Chemistry), Moscow: Znanie, 1976.

    Google Scholar 

  25. Porcel, E., Liehn, S., Remita, H., Usami, N., Kobayashi, K., Furusawa, Y., Le Sech, C., and Lacombe, S., Nanotechnology, 2010, vol. 21, p. 85103.

    Article  Google Scholar 

  26. Teow, Y. and Valiyaveettil, S., Nanoscale, 2010, vol. 2, p. 2607.

    Article  CAS  Google Scholar 

  27. Schneider, E., Chavali, M., Collazo, L., Mironova, T., and Rafailovich, M., Cancer Res., 2012, vol. 72, no. 8, Suppl. 1, Abstract no. 1956.

    Google Scholar 

  28. Asharani, P.V., Lianwu, Y., Gong, Z., and Valiyaveettil, S., Nanotoxicology, 2011, vol. 5, p. 43.

    Article  CAS  Google Scholar 

  29. Manikandan, M., Hasan, N., and Wu, H.F., Biomaterials, 2013, vol. 34, p. 5833.

    Article  CAS  Google Scholar 

  30. Mosmann, T., J. Immunol. Methods, 1983, vol. 65, p. 55.

    Article  CAS  Google Scholar 

  31. MULTIDRAG. Colorimetric (MTT) kit for cell survival and proliferation. Catalog number: CT02.

  32. Zhou, M., Wang, B., Rozynek, Z., Xie, Z., Fossum, J.O., Yu, X., and Raaen, S., Nanotechnology, 2009, vol. 20, p. 505606.

    Article  Google Scholar 

  33. Ponti, J., Colognato, R., Franchini, F., Gioria, S., Simonelli, F., Abbas, K., Uboldi, C., Kirkpatrick, C.J., Holzwarth, U., and Rossi, F., Nanotoxicology, 2009, vol. 3, p. 296.

    Article  CAS  Google Scholar 

  34. Villiers, C.L., Freitas, H., Couderc, R., Villiers, M.-B., and Marche, P.N., J. Nanopart. Res., 2010, vol. 12, p. 55.

    Article  CAS  Google Scholar 

  35. Mohammadi, H., Abedi, A., Akbarzadeh, A., Mokhtari, M.J., Shahmabadi, H.E., Mehrabi, M.R., Javadian, S., and Chiani, M., Int. Nano Lett., 2013, vol. 3, Article no. 28.

  36. Niidome, T., Yamagata, M., Okamoto, Y., Akiyama, Y., Takahashi, H., Kawano, T., Katayama, Y., and Niidome, Y., J. Control. Release, 2006, vol. 114, p. 343.

    Article  CAS  Google Scholar 

  37. Hikosaka, K., Kim, J., Kajita, M., Kanayama, A., and Miyamoto, Y., Colloids Surf. B, 2008, vol. 66, p. 195.

    Article  CAS  Google Scholar 

  38. Huang, X., PhD Thesis (Georgia Inst. of Technology, 2007).

  39. Gehrke, H., Pelka, J., Hartinger, C.G., Blank, H., Bleimund, F., Schneider, R., Gerthsen, D., Bräse, S., Crone, M., Türk, M., and Marko, D., Arch. Toxicol., 2011, vol. 85, p. 799.

    Article  CAS  Google Scholar 

  40. Estrela-Llopis, V.R., Borodinova, T.I., and Yurkova, I.N., Extracellular // In: Nanoscience, Colloidal and Interfacial Aspects, Starov, V., Ed., CRC Press, 2010, p. 307.

    Chapter  Google Scholar 

  41. Moore, B.G. and Tischer, R.G., Science (Washington, D. C.) 1964, vol. 145, p. 586.

    Article  CAS  Google Scholar 

  42. Hodnett, E.M., Amirmoazzami, J., and Tai, J.T.H., J. Med. Chem., 1978, vol. 21, p. 652.

    Article  CAS  Google Scholar 

  43. Daba, A.S. and Ezeronye, O.U., Afr. J. Biotechnol., 2003, vol. 2, p. 672.

    Google Scholar 

  44. Xu, A.H., Chen, H.S., Sun, B.C., Xiang, X.R., Chu, Y.F., Zhai, F., and Jia, L.C., World J. Gastroenterol., 2003, vol. 9, p. 2424.

    CAS  Google Scholar 

  45. Misra, S., Toole, B.P., and Ghatak, S., J. Biol. Chem., 2006, vol. 281, p. 34936.

    Article  CAS  Google Scholar 

  46. Barchi, J.J., Rittenhouse-Olson, K., and Svarovsky, S., WO Patent 2005046722 A3 USA, 2005.

  47. Umezawa, I. and Komiyama, K., US Patent 4533548, 1985.

  48. Kralovec, J.A., US Patent 6974576, 2005.

  49. www.abdchlorella.com/index.php/chlorella-facts

  50. Silva, A.L. and Trindade, T., in Advances in Nanocomposite Technology, Hashim, A., Ed., InTech, 2011, p. 275.

  51. Vladimirova, M.G. and Semenenko, V.E., Intensivnaya kul’tura odnokletochnykh vodoroslei (Intensive Culture of Unicellular Algae), Moscow: Akad. Nauk SSSR, 1962.

    Google Scholar 

  52. Guilbert, L.J. and Iscove, N.N., Nature (London), 1976, vol. 263, p. 594.

    Article  CAS  Google Scholar 

  53. Mironov, A.A., Komissarchik, Ya.Yu., and Mironov, V.A., Metody elektronnoi mikroskopii v biologii i meditsine (Electron Microscopy Methods in Biology and Medicine), St. Petersburg: Nauka, 1994.

    Google Scholar 

  54. Estrela-L’opis, V.R., Ovcharenko, F.D., and Yurkova, I.N., in Fiziko-khimicheskaya mekhanika i liofil’nost’ dispersnykh sistem (Physicochemical Mechanics and Lyophilicity of Disperse Systems), Kiev: Naukova Dumka, 1991, no. 22, p. 1.

    Google Scholar 

  55. Zakharova, I.Ya. and Kosenko, L.V., Metody issledovaniya polisakharidov mikroorganizmov (Methods for Investigation of Microorganism Polysaccharides), Kiev: Naukova Dumka, 1982.

    Google Scholar 

  56. Lupu, A.R. and Popescu, T., Toxicol. in Vitro, 2013, vol. 27, p. 1445.

    Article  CAS  Google Scholar 

  57. Kong, B., Seog, J.H., Graham, L.M., and Lee, S.B., Nanomedicine, 2011, vol. 6, p. 929.

    Article  CAS  Google Scholar 

  58. Stone, V., Johnston, H., and Schins, R.P.F., Crit. Rev. Toxicol., 2009, vol. 39, p. 613.

    Article  CAS  Google Scholar 

  59. Dhawan, A. and Sharma, V., Anal. Bioanal. Chem., 2010, vol. 398, p. 589.

    Article  CAS  Google Scholar 

  60. http://www.rndsystems.com/index.aspx

  61. Shukla, S., Priscilla, A., Banerjee, M., Bhonde, R.R., Ghatak, J., Satyam, P.V., and Sastry, M., Chem. Mater., 2005, vol. 17, p. 5000.

    Article  CAS  Google Scholar 

  62. Estrela-Lopis, V.R., Ul’berg, Z.R., and Kosenko, O.A., Colloid J., 2009, vol. 71, p. 125.

    Article  CAS  Google Scholar 

  63. Stavrovskaya, A.A., Biochemistry, 2000, vol. 65, p. 95.

    CAS  Google Scholar 

  64. Stavrovskaya, A.A., Sorosovskii Obrazovat. Zh., 2001, vol. 7, no. 7, p. 17.

    Google Scholar 

  65. Asharani, P.V., Xinyi, N., Hande, M.P., and Valiyaveettil, S., Nanomedicine, 2010, vol. 5, p. 51.

    Article  CAS  Google Scholar 

  66. Mukherjee, P., Bhattacharya, R., Wang, P., Wang, L., Basu, S., Nagy, J.A., Atala, A., Mukhopadhyay, D., and Soker, S., Clin. Cancer Res., 2005, vol. 11, p. 3530.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ovcharenko Institute of Biocolloid Chemistry, National Academy of Sciences of Ukraine, pr. Vernadskogo 42, Kyiv, 03044, Ukraine

    V. R. Estrela-Llopis, A. V. Chevichalova & E. V. Ryzhuk

  2. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Sciences of Ukraine, Vasil’kovskaya ul. 45, Kyiv, 03022, Ukraine

    N. A. Trigubova

Authors
  1. V. R. Estrela-Llopis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Chevichalova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. A. Trigubova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. V. Ryzhuk
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. R. Estrela-Llopis.

Additional information

Original Russian Text © V.R. Estrela-Llopis, A.V. Chevichalova, N.A. Trigubova, E.V. Ryzhuk, 2014, published in Kolloidnyi Zhurnal, 2014, Vol. 76, No. 5, pp. 659–672.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Estrela-Llopis, V.R., Chevichalova, A.V., Trigubova, N.A. et al. Heterocoagulation of polysaccharide-coated platinum nanoparticles with ovarian-cancer cells. Colloid J 76, 609–621 (2014). https://doi.org/10.1134/S1061933X14050081

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1061933X14050081

Keywords

Search

Navigation