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Zinc phthalocyanine-based water-soluble thiolated photosensitizer and its conjugates with gold nanoparticles: Synthesis and spectral properties

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Abstract

A new photosensitizer, monoconjugate of zinc octa-4,5-carboxy-phthalocyanine with L-cysteine, which is rather readily soluble in water, has been synthesized and characterized. The chemisorption of its molecules on the surface of gold nanoparticles with different sizes has been studied. A comparative analysis of the spectral characteristics of the synthesized conjugates of gold nanoparticles with the photosensitizer has shown that the photosensitizer grafted to gold nanoparticles exhibits rather intense fluorescence. Therefore, such conjugates can be used for photodynamic therapy of tumors.

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Authors and Affiliations

  1. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow, 119071, Russia

    O. V. Dement’eva, M. M. Vinogradova, V. A. Ogarev & V. M. Rudoy

  2. Higher Chemical College, Russian Academy of Sciences, Mendeleev University of Chemical Technology, Miusskaya pl. 9, Moscow, 125047, Russia

    M. M. Vinogradova

  3. State Scientific Center, Research Institute of Organic Intermediates and Dyes, ul. Bol’shaya Sadovaya 1/4, Moscow, 123995, Russia

    E. A. Luk’yanets & L. I. Solov’eva

Authors
  1. O. V. Dement’eva
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  2. M. M. Vinogradova
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  3. E. A. Luk’yanets
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  4. L. I. Solov’eva
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  5. V. A. Ogarev
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  6. V. M. Rudoy
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Correspondence to O. V. Dement’eva.

Additional information

Original Russian Text © O.V. Dement’eva, M.M. Vinogradova, E.A. Luk’yanets, L.I. Solov’eva, V.A. Ogarev, V.M. Rudoy, 2014, published in Kolloidnyi Zhurnal, 2014, Vol. 76, No. 5, pp. 587–593.

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Dement’eva, O.V., Vinogradova, M.M., Luk’yanets, E.A. et al. Zinc phthalocyanine-based water-soluble thiolated photosensitizer and its conjugates with gold nanoparticles: Synthesis and spectral properties. Colloid J 76, 539–545 (2014). https://doi.org/10.1134/S1061933X14050068

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  • DOI: https://doi.org/10.1134/S1061933X14050068

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