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Laser Physics

, Volume 20, Issue 2, pp 551–556 | Cite as

Analysis of the penetration of a caffeine containing shampoo into the hair follicles by in vivo laser scanning microscopy

  • J. LademannEmail author
  • H. Richter
  • S. Schanzer
  • A. Klenk
  • W. Sterry
  • A. Patzelt
Laser Methods in Chemistry, Biology, and Medicine

Abstract

In previous in vitro investigations, it was demonstrated that caffeine is able to stimulate the hair growth. Therefore, a penetration of caffeine into the hair follicle is necessary. In the present study, in vivo laser scanning microscopy (LSM) was used to investigate the penetration and storage of a caffeine containing shampoo into the hair follicles. It was shown that a 2-min contact time of the shampoo with the skin was enough to accumulate significant parts of the shampoo in the hair follicles. A penetration of the shampoo up to a depth of approx. 200 μm could be detected, which represents the detection limit of the LSM. At this depth, the close network of the blood capillaries surrounding the hair follicles commences. Even after 24 h, the substance was still detectable in the hair follicles. This demonstrates the long-term reservoir function of the hair follicles for topically applied substances such as caffeine.

Keywords

Caffeine Stratum Corneum Hair Follicle Skin Surface Laser Phys 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • J. Lademann
    • 1
    Email author
  • H. Richter
    • 1
  • S. Schanzer
    • 1
  • A. Klenk
    • 2
  • W. Sterry
    • 1
  • A. Patzelt
    • 1
  1. 1.Center of Experimental and Applied Cutaneous Physiology (CCP), Department of Dermatology and AllergologyCharité—UniversitätsmedizinBerlinGermany
  2. 2.Alcina Cosmetic Dr. Kurt Wolff GmbH and Co. KGBielefeldGermany

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