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Development of novel formulations for photodynamic therapy on the basis of amphiphilic polymers and porphyrin photosensitizers. Pluronic influence on photocatalytic activity of porphyrins

  • Biophotonics
  • Published:
Laser Physics

Abstract

Effect of ethylene and propylene oxide tri-block copolymers (Pluronics) on the photocatalytic activity of tree porphyrins differing by their hydrophobicity was studied. It was shown that Pluronics induce considerable increase in the photocatalytic activity of the tetraphenylporphyrin, hematoporphyrin disodium salt (Dimegine) and relatively hydrophilic N-methyl-bis-glucamine salt of chlorine e6 (Photoditazine) in the reaction of photooxidation of tryptophan in water solution. This effect was maximal for Pluronics F127 and P85 with intermediate hydrophobicity, while more hydrophilic F68 and more hydrophobic L61 were less effective. Pluronic effect on the photocatalytic activity of tetraphenylporphyrin and dimegine is attributed to their disaggregation in water solution, while PD activity is elevated due to the local concentrating of the photocatalyst and the substrate within micellar volume. It was found by AFM that the structure of Pluronic F127 thin films prepared by water solution evaporation on mica surface significantly changed in the presence of porphyrin. This effect can be attributed to the interaction of Pluronics with porphyrins in water solution.

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References

  1. T. C. Zhu and J. C. Finlay, Med. Phys. 7, 3127 (2008).

    Article  Google Scholar 

  2. B. C. Wilson and M. S. Patterson, Phys. Med. Biol. 53(9), 61 (2008).

    Article  Google Scholar 

  3. W. W. Chin, P. W. Heng, P. S. Thong, R. Bhuvaneswari, W. Hirt, S. Kuenzel, K. C. Soo, and M. Olivo, Eur. J. Pharm. Biopharm. 69(3), 1083 (2008).

    Article  Google Scholar 

  4. W. W. Chin, P. W. Heng, and M. Olivo, BMC Pharmacol. 7, 1 (2007).

    Article  Google Scholar 

  5. B. Li, E. H. Moriyama, F. Li, M. T. Jarvi, C. Allen, and B. C. Wilson, Photochem. Photobiol. 83(6), 1505 (2007).

    Article  Google Scholar 

  6. H. A. Isakau, M. V. Parkhats, V. N. Knyukshto, B. M. Dzhagarov, E. P. Petrov, and P. T. Petrov, J. Photochem. Photobiol. B 92(3), 165 (2008).

    Article  Google Scholar 

  7. A. Kubin, H. G. Loew, U. Burner, G. Jessner, H. Kolbabek, and F. Wierrani, Pharmazie. 63(4), 263 (2008).

    Google Scholar 

  8. C. Kojima, Y. Toi, A. Harada, and K. Kono, Bioconjug Chem. 18(3), 663 (2007).

    Article  Google Scholar 

  9. M. Regehly, K. Greish, F. Rancan, H. Maeda, F. Böhm, and B. Röder, Bioconjug Chem. 18(2), 494 (2007).

    Article  Google Scholar 

  10. J. Van Steveninck, J. W. Lagerberg, P. Charlesworth, T. M. Dubbelman, and T. G. Truscott, Biochim. Biophys. Acta. 1201(1), 23 (1994)

    Google Scholar 

  11. S. L. Rakestraw, W. E. Ford, R. G. Tompkins, M. A. Rodgers, W. P. Thorpe, and M. L. Yarmush, Biotechnol. Prog. 8(1), 30 (1992).

    Article  Google Scholar 

  12. A. C. Allison and N. E. Byars, J. Immunol. Methods. 95, 157 (1986).

    Article  Google Scholar 

  13. K. C. Lowe and F. H. Armstrong, Adv. Exp. Med. Biol. 277, 267 (1990).

    Google Scholar 

  14. A. G. Justicz, W. V. Farnsworth, M. S. Soberman, M. V. Tuvlin, G. D. Bonner, R. L. Hunter, and D. Martino-Saltzman, Am. Heart J. 122, 671 (1991).

    Article  Google Scholar 

  15. M. E. Carr, R. Rowers, and M. R. Jones, Thrombosis Haemostasis. 66, 565 (1991).

    Google Scholar 

  16. Z. Sezgin, N. Yuksel, and T. Baykara, Int. J. Pharm. 332(1–2), 161 (2007).

    Article  Google Scholar 

  17. L. Bourre, S. Thibaut, A. Briffaud, Y. Lajat, and T. Patrice, Pharmacol. Res. 45(2), 159 (2002).

    Article  Google Scholar 

  18. R. K. Chowdhary, I. Sharif, N. Chansarkar, D. Dolphin, L. Ratkay, S. Delaney, and H. Meadows, J. Pharm. Pharm. Sci. 6(2), 198 (2003).

    Google Scholar 

  19. R. Pohloudek-Fabini and Th. Beyrich, Organic Analysis (Akademische Verlagsgesellschaft, Geest & Portig K.-G., Leipzig, 1975).

    Google Scholar 

  20. V. E. Belyaev, A. B. Solovieva, N. N. Glagolev, G. V. Vstovsky, S. F. Timashev, A. V. Krivandin, O. V. Shatalova, and V. N. Luzgina, in Proc. of SPIE, Prague, Czechia, 2005, current papers “Laser Use in Oncology III”, pp. 148–153.

  21. R. Schmidt and C. Tanielian, J. Phys. Chem. A 104, 3177 (2000).

    Article  Google Scholar 

  22. J. Dairou, C. Vever-Bizet, and D. Brault, Photochem. Photobiol. 75(3), 229 (2002).

    Article  Google Scholar 

  23. J. D. Spikes and J. C. Bommer, J. Photochem. Photobiol. B 17, 135 (1993).

    Article  Google Scholar 

  24. A. Roby, S. Erdogan, and V. P. Torchilin, Eur. J. Pharm. Biopharm. 62, 235 (2006).

    Article  Google Scholar 

  25. Y.-L. Su, J. Wang, and H.-Z. Liu, J. Colloid Interface Sci. 251, 417 (2002).

    Article  Google Scholar 

  26. T. M. Zhiyentayev, N. S. Melik-Nubarov, E. A. Litmanovich, N. A. Aksenova, N. N. Glagolev, and A. B. Solovieva, Polymer Sci. (Rus.) 5, (2009, in press).

  27. S. A. Gerhardt, J. W. Lewis, D. S. Kliger, J. Z. Zhang, and U. Simonis, J. Phys. Chem. 107, 2763 (2003).

    Google Scholar 

  28. K. Mortensen and J. S. Pedersen, Macromolecules 26, 805 (1993).

    Article  Google Scholar 

  29. M. Malmsten and B. Lindman, Macromolecules 25, 5440 (1992).

    Article  Google Scholar 

  30. N. A. Aksenova, N. N. Glagolev, V. T. Shashkova, N. L. Zaichenko, L. S. Kol’tsova, A. I. Shienok, P. S. Timashev, B. I. Zapadinskii, and A. B. Solovieva, Rus. J. Phys. Chem. 82, 1759 (2008).

    Google Scholar 

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Authors and Affiliations

  1. Institution of Russian Academy of Sciences Semenov Institute of Chemical Physics RAS, ul. Kosygina 4, Moscow, 119991, Russia

    A. B. Solovieva, N. A. Aksenova, N. N. Glagolev & V. A. Timofeeva

  2. Moscow State University, Moscow, 119992, Russia

    N. S. Melik-Nubarov, T. M. Zhiyentayev & E. A. Litmanovich

  3. Laser Medicine Center, Studencheskaya ul. 40, bild. 1, Moscow, 121165, Russia

    P. I. Tolstih & I. I. Kuleshov

  4. Blokhin ROSC, Kashirskoe sh. 24, Moscow, 115478, Russia

    A. V. Ivanov

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  1. A. B. Solovieva
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  2. N. S. Melik-Nubarov
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  3. T. M. Zhiyentayev
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  4. P. I. Tolstih
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  5. I. I. Kuleshov
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  6. N. A. Aksenova
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  7. E. A. Litmanovich
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  8. N. N. Glagolev
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  9. V. A. Timofeeva
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  10. A. V. Ivanov
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Correspondence to A. B. Solovieva.

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Original Text © Astro, Ltd., 2009.

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Solovieva, A.B., Melik-Nubarov, N.S., Zhiyentayev, T.M. et al. Development of novel formulations for photodynamic therapy on the basis of amphiphilic polymers and porphyrin photosensitizers. Pluronic influence on photocatalytic activity of porphyrins. Laser Phys. 19, 817–824 (2009). https://doi.org/10.1134/S1054660X09040410

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  • DOI: https://doi.org/10.1134/S1054660X09040410

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