Abstract
The excitation of external electrode of focused photoacoustic (PA) detector by the backscattered laser radiation can ensure a cost-effective upgrade from single-modality PA microscopy to dual-modality PA/US imaging. In this work we approbated thermoelastic generation of probing ultrasonic pulses for bimodal photoacoustic (PA) and optically mediated Ultrasound (US) microscopy in vivo, using single optical pulse delivered from tunable laser to form both PA and US A-scans. The presented results of bimodal in vivo visualization of rat brain provide with the experimental evidence, that the proposed approach can be used for both functional and structural bioimaging simultaneously.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
T. D. Khohlova, I. M. Pelivanov, and A. A. Karabutov, Acoust. Phys. 55(4–5), 674–684 (2009).
Y. Y. Petrov, I. Y. Petrova, I. A. Patrikeev, R. O. Esenaliev, and D. S. Prough, Opt. Lett. 31(12), 1827–1829 (2006).
L. V. Wang and S. Hu, Science 335, 1458–1462 (2012).
J. Powers and F. Kremkau, Interface Focus 1(4), 477–489 (2011).
J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, IEEE Trans. Med. Imaging 24, 436–440 (2005).
S. Y. Nam, L. M. Ricles, L. J. Suggs, and S. Y. Eme- lianov, PLoS ONE 7(5), e37267 (2012).
Y. Jiang, A. Forbrich, T. Harisson, and R. J. Zemp, J. Biomed. Opt. 17(3), 036012 (2012).
J. Jose, R. G. H. Willemink, S. Resink, D. Piras, J. C. G. van Hespen, C. H. Slump, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, Opt. Express 19(3), 2093–2104 (2011).
B. Y. Hsieh, S. L. Chen, T. Ling, L. J. Guo, and P. C. Li, Opt. Express 20(2), 1588–1596 (2012).
K. Passler, R. Nuster, S. Gratt, P. Burgholzer, T. Berer, and G. Paltauf, Biomed. Opt. Express 1(1), 318–323 (2010).
H. W. Baac, T. Ling, S. Ashkenazi, S.-W. Huang, and L. J. Guo, Proc. Soc. Photo Opt. Instrum. Eng. 7564(1), 75642M (2010).
D. S. Kopylova and I. M. Pelivanov, J. Acoust. Soc. Am. 130(4), EL213–EL218 (2011).
K. Maslov, G. Stoica, and L. V. Wang, Opt. Lett. 30(6), 625–627 (2005).
P. Subochev, A. Katichev, A. Morozov, A. Orlova, V. Kamensky, and I. Turchin, Opt. Lett. 37(22), 4606–4608 (2012).
A. D. Nozdrachev and E. L. Polyakov, The Rat’s Anatomy (Lan’, Saint-Petersburg, 2001) [in Russian].
Author information
Authors and Affiliations
Additional information
Original Russian Text © P.V. Subochev, A.G. Orlova, I.V. Turchin, A.M. Sergeev, 2014, published in Doklady Akademii Nauk, 2014, Vol. 454, No. 4, pp. 396–398.
The article was translated by the authors.
Rights and permissions
About this article
Cite this article
Subochev, P.V., Orlova, A.G., Turchin, I.V. et al. Method of bimodal photoacoustic and ultrasound microscopy for simultaneous structural and functional diagnostics of biotissues. Dokl. Phys. 59, 59–61 (2014). https://doi.org/10.1134/S1028335814020037
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1028335814020037