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Investigation of the Biodistribution of Gd0.5La0.5F3:Eu Nanoparticles in the Internal Tissues of Laboratory Mice Using X-Ray Computed Tomography and X-Ray Fluorescence Analysis

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Abstract—

The biodistribution of nanoparticles of Gd0.5La0.5F3:Eu(15%) X-ray phosphor in the body and tissues of internal organs of balb/c laboratory mice is studied. The Gd0.5La0.5F3:Eu(15%) nanoparticles are obtained by hydrothermal synthesis at 250°С for 24 h. Using X-ray powder diffraction, transmission electron microscopy, and dynamic light scattering, it is shown that a hexagonal phase is formed in the resulting sample and the average size of nanoparticles varies in the range from 30 to 40 nm. In vivo experiments show that with the intravenous administration of an aqueous solution of nanoparticles, the drug is accumulated mainly in the liver and spleen and the maximum concentration is reached during the first day. The results of post-mortem analysis of tissues using micro-computed tomography (CT) show that the nanoparticles form conglomerates; their distribution over the volume of the organ is homogeneous. The X-ray fluorescence analysis of liver- and spleen-tissue fragments allows for elemental analysis and mapping. The distribution maps of heavy elements in the composition of nanoparticles (Gd, La, Eu) are similar to Fe distribution maps, which indicates the uniform distribution of Gd0.5La0.5F3:Eu(15%) nanoparticles in the pulp of the internal tissues of the liver and spleen.

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Funding

This study was supported by the Russian Science Foundation (grant no. 19-15-00305).

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Authors and Affiliations

  1. International Smart Materials Research Institute, Southern Federal University, 344090, Rostov-on-Don, Russia

    O. E. Polozhentsev, I. A. Pankin & A. V. Soldatov

  2. National Medical Research Centre for Oncology of the Ministry of Health of Russia, 344037, Rostov-on-Don, Russia

    D. V. Khodakova & A. S. Goncharova

Authors
  1. O. E. Polozhentsev
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  2. D. V. Khodakova
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  3. A. S. Goncharova
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  4. I. A. Pankin
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  5. A. V. Soldatov
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Correspondence to O. E. Polozhentsev.

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Translated by S. Rostovtseva

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Polozhentsev, O.E., Khodakova, D.V., Goncharova, A.S. et al. Investigation of the Biodistribution of Gd0.5La0.5F3:Eu Nanoparticles in the Internal Tissues of Laboratory Mice Using X-Ray Computed Tomography and X-Ray Fluorescence Analysis. J. Surf. Investig. 17, 947–953 (2023). https://doi.org/10.1134/S1027451023050099

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  • DOI: https://doi.org/10.1134/S1027451023050099

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