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Production and Investigation of Radiopharmaceutical Nanoconstruction [212Pb]DOTATATE for Therapy of Malignant Neoplasms

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Abstract

A method for obtaining radiopharmaceutical nanoconstruction [212Pb]DOTATATE for investigations in the field of neuroendocrine tumors therapy has been developed. A laboratory generator of β-emitting radionuclide 212Pb with an operating efficiency of 40% has also been developed. To determine the cytotoxic effect of the [212Pb]DOTATATE complex, somatostatin receptor-expressing pancreatic cancer cells (Rin-m5F cell line) were incubated with [212Pb]DOTATATE for 22 h; cell survival was determined using Presto Blue analysis.

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Funding

The work was supported by the NRC “Kurchatov Institute” (no. 1363).

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Authors and Affiliations

  1. National Research Center “Kurchatov Institute,”, 123182, Moscow, Russia

    K. Kokov, A. Larkin, K. Makoveeva, A. Moiseeva, V. Panchenko, M. Proshin, I. Reshetov & D. Chuvilin

  2. Faculty of Physics, Moscow State University, 11991, Moscow, Russia

    K. Kokov, V. Panchenko & D. Chuvilin

  3. Sechenov First Moscow State Medical University, 119146, Moscow, Russia

    A. Demchenko, A. Lyundup & I. Reshetov

  4. Faculty of Chemistry, Moscow State University, 119991, Moscow, Russia

    B. Egorova

Authors
  1. K. Kokov
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  2. A. Demchenko
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  3. B. Egorova
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  4. A. Larkin
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  5. A. Lyundup
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  6. K. Makoveeva
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  7. A. Moiseeva
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  8. V. Panchenko
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  9. M. Proshin
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  10. I. Reshetov
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  11. D. Chuvilin
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Correspondence to K. Kokov.

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Kokov, K., Demchenko, A., Egorova, B. et al. Production and Investigation of Radiopharmaceutical Nanoconstruction [212Pb]DOTATATE for Therapy of Malignant Neoplasms. J. Surf. Investig. 14 (Suppl 1), S99–S104 (2020). https://doi.org/10.1134/S102745102007023X

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  • DOI: https://doi.org/10.1134/S102745102007023X

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