A method for generating cefazolin aerosol particles with sizes from 80 to 1400 nm is presented. By an example of pulmonary administration of the aerosol on laboratory animals (mice), it is shown that this cefazolin delivery technique is close in efficiency to intravenous injection.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price includes VAT (USA)
Tax calculation will be finalised during checkout.
R. Gaul, J. M. Ramsey, A. Heise, S.-A. Cryan, and C. M. Greene, “Nanotechnology approaches to pulmonary drug delivery: Targeted delivery of small molecule and gene-based therapeutics to the lung,” in Design of Nanostructures for Versatile Therapeutic Applications (Elsevier, Oxford, 2018).
Pharmaceutical Inhalation Aerosol Technology, Ed. by A.J. Hickey (Marcel Dekker, New York, 2004).
M. D. Mashkovskii, Drugs (Novaya Volna, Moscow, 2001) vol. 2 [in Russian].
S. V. Valiulin, A. M. Baklanov, S. N. Dubtsov, V. G. Mitrochenko, P. P. Moiseenko, and A. A. Onishchuk, “Diffusion aerosol spectrometer for measurements of the size distribution and concentrations of nano- and submicron particles, ” Pribory Tekhnika Eksperimenta. No. 1, 145–146 (2019).
A. A. Onischuk, S. V. Valiulin, A. M. Baklanov, P. P. Moiseenko, and V. G. Mitrochenko, “Determination of the aerosol particle size distribution by means of the diffusion battery: Analytical inversion,” Aerosol Sci. Technol. 52 (8), 841–853 (2018).
P. Raist, The Aerosols.Introduction in the Theory (1986).
K. Kunicki and J. Was, “Simple HPLC method for cefazolin determination in human serum—validation and stability testing,” J. Chromatogr., B 911 (12), 133–139 (2012).
E. C. Palma, J. V. Laureano, B. V. de Araujo, N. G. Meinhardt, A. T. Stein, and T. D. Costa, “Fast and sensitive HPLC/UV method for cefazolin quantification in plasma and subcutaneous tissue microdialysate of humans and rodents applied to pharmacokinetic studies in obese individuals,” Biomed. Chromatogr. 32, e4254 (1–11) (2018).
N. Hasan, N. Sher, F. A. Siddiqui, M. Ahmad, N. Shafi, A. A. Sial, and M. T. Baig, “Novel HPLC method for quantitative determination of cefazolin sodium in pharmaceutical formulations,” Res. Rep. Med. Chem. 2013 (3), 21–28 (2013).
S. V. Valiulin, A. A. Onischuk, A. M. Baklanov, and S. N. Dubtsov, S. V. An’kov, T. G. Tolstikova, M. E. Plokhotnichenko, G. G. Dultseva, and P. S. Mazunina, “Excipient-free isoniazid aerosol administration in mice: Evaporation-nucleation particle generation, pulmonary delivery and body distribution,” Int. J. Pharm. 563, 101–109 (2019).
A. D. Arms and C. C. Travis, Reference Physiological Parameters in Pharmacokinetic Modeling. EPA Report no. EPA/600/6-88/004 (U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Washington, DC, 1988).
The study was supported by the Russian Science Foundation (project no. 19-73-10 143).
The authors declare that they have no conflicts of interest.
Translated by A. Nikol’skii
About this article
Cite this article
Bazhina, A.A., Valiulin, S.V., Baklanov, A.M. et al. A Method for Generating an Aerosol of the Antibacterial Medicine Cefazolin. Atmos Ocean Opt 33, 555–558 (2020). https://doi.org/10.1134/S1024856020050048
- pulmonary administration