Skip to main content

A Method for Generating an Aerosol of the Antibacterial Medicine Cefazolin

Abstract

A method for generating cefazolin aerosol particles with sizes from 80 to 1400 nm is presented. By an example of pulmonary administration of the aerosol on laboratory animals (mice), it is shown that this cefazolin delivery technique is close in efficiency to intravenous injection.

This is a preview of subscription content, access via your institution.

Fig. 1.
Fig. 2.
Fig. 3.

REFERENCES

  1. 1

    R. Gaul, J. M. Ramsey, A. Heise, S.-A. Cryan, and C. M. Greene, “Nanotechnology approaches to pulmonary drug delivery: Targeted delivery of small molecule and gene-based therapeutics to the lung,” in Design of Nanostructures for Versatile Therapeutic Applications (Elsevier, Oxford, 2018).

    Google Scholar 

  2. 2

    Pharmaceutical Inhalation Aerosol Technology, Ed. by A.J. Hickey (Marcel Dekker, New York, 2004).

    Google Scholar 

  3. 3

    M. D. Mashkovskii, Drugs (Novaya Volna, Moscow, 2001) vol. 2 [in Russian].

    Google Scholar 

  4. 4

    S. V. Valiulin, A. M. Baklanov, S. N. Dubtsov, V. G. Mitrochenko, P. P. Moiseenko, and A. A. Onishchuk, “Diffusion aerosol spectrometer for measurements of the size distribution and concentrations of nano- and submicron particles, ” Pribory Tekhnika Eksperimenta. No. 1, 145–146 (2019).

    Google Scholar 

  5. 5

    A. A. Onischuk, S. V. Valiulin, A. M. Baklanov, P. P. Moiseenko, and V. G. Mitrochenko, “Determination of the aerosol particle size distribution by means of the diffusion battery: Analytical inversion,” Aerosol Sci. Technol. 52 (8), 841–853 (2018).

    ADS  Article  Google Scholar 

  6. 6

    P. Raist, The Aerosols.Introduction in the Theory (1986).

    Google Scholar 

  7. 7

    K. Kunicki and J. Was, “Simple HPLC method for cefazolin determination in human serum—validation and stability testing,” J. Chromatogr., B 911 (12), 133–139 (2012).

    Article  Google Scholar 

  8. 8

    E. C. Palma, J. V. Laureano, B. V. de Araujo, N. G. Meinhardt, A. T. Stein, and T. D. Costa, “Fast and sensitive HPLC/UV method for cefazolin quantification in plasma and subcutaneous tissue microdialysate of humans and rodents applied to pharmacokinetic studies in obese individuals,” Biomed. Chromatogr. 32, e4254 (1–11) (2018).

  9. 9

    N. Hasan, N. Sher, F. A. Siddiqui, M. Ahmad, N. Shafi, A. A. Sial, and M. T. Baig, “Novel HPLC method for quantitative determination of cefazolin sodium in pharmaceutical formulations,” Res. Rep. Med. Chem. 2013 (3), 21–28 (2013).

    Google Scholar 

  10. 10

    S. V. Valiulin, A. A. Onischuk, A. M. Baklanov, and S. N. Dubtsov, S. V. An’kov, T. G. Tolstikova, M. E. Plokhotnichenko, G. G. Dultseva, and P. S. Mazunina, “Excipient-free isoniazid aerosol administration in mice: Evaporation-nucleation particle generation, pulmonary delivery and body distribution,” Int. J. Pharm. 563, 101–109 (2019).

    Article  Google Scholar 

  11. 11

    A. D. Arms and C. C. Travis, Reference Physiological Parameters in Pharmacokinetic Modeling. EPA Report no. EPA/600/6-88/004 (U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Washington, DC, 1988).

Download references

Funding

The study was supported by the Russian Science Foundation (project no. 19-73-10 143).

Author information

Affiliations

Authors

Corresponding author

Correspondence to S. V. Valiulin.

Ethics declarations

The authors declare that they have no conflicts of interest.

Additional information

Translated by A. Nikol’skii

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bazhina, A.A., Valiulin, S.V., Baklanov, A.M. et al. A Method for Generating an Aerosol of the Antibacterial Medicine Cefazolin. Atmos Ocean Opt 33, 555–558 (2020). https://doi.org/10.1134/S1024856020050048

Download citation

Keywords:

  • nanoparticles
  • aerosol
  • pulmonary administration
  • cefazolin
  • antibiotic