Abstract
In this work, very simple and swift method for the assessment of synthetic steroid Tibolone, which was banned by World Anti-Doping Agency (WADA) has been developed. A glassy carbon electrode modified with CuO nanoparticles and multi-walled carbon nanotubes was used. The effect of scan rate, pH of the medium, and concentration of nano-suspension has been studied using cyclic voltammetry in 0.1 M phosphate buffer solution. Linear sweep voltammetry was used for the quantification of Tibolone. The modified electrodes shows linearity range of 15 to 80 μM Tibolone with limit of detection of 1.05 μM and limit of quantification of 3.51 μM, respectively. Further the present method was successfully applied to determine Tibolone in pharmaceutical formulations and urine sample.
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This work was carried out with the financial support of Vision Group on Science and Technology, Government of Karnataka, India (VGST/RGS-F/GRD-923/2019-20/2020-21/198 dated 10-11-2020).
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Hegde, R.N., Vishwanatha, P. & Nandibewoor, S.T. Voltammetric Determination of Tibolone on a Nano-Composite Electrode. Russ J Electrochem 59, 320–324 (2023). https://doi.org/10.1134/S1023193523040080
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DOI: https://doi.org/10.1134/S1023193523040080