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A Screen-Printed Electrochemical Sensor Based on Iron Molybdenum Oxide Magnetic Nanocomposite for Simultaneous Detection of Acetaminophen and Isoniazid

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Abstract

In this study, iron molybdenum oxide magnetic nanocomposite (Fe2MoO4) was prepared and characterized by different characterization techniques. An electrochemical sensing based on screen printed electrodes (SPE) modified with Fe2MoO4 (Fe2MoO4/SPE) facilitate the detection of acetaminophen (AC) in phosphate buffer solution (PBS) at pH 7.0 by using voltammetry technique. The Fe2MoO4/SPE shows enhanced electrocatalytic activity compared to unmodified SPE. As a result, the Fe2MoO4/SPE was used for further electrochemical studies. The AC concentration determination was in the range 0.15 to 500.0 µM and the limit of detection (LOD) was found to be 0.05 µM. From the scan rate study the oxidation and reduction of AC was found to be diffusion controlled and simultaneous detection of AC and isoniazid (INZ) were well done in differential pulse voltammetric (DPV) technique. Moreover the stability and reproducibility of Fe2MoO4/SPE was studied. Moreover, this sensor was further used to detect AC and INZ in AC tablet, INZ tablet and urine samples with satisfactory results.

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Authors and Affiliations

  1. Department of Chemistry, Shahid Bahonar University, Kerman, Iran

    Fariba Garkani Nejad & Iran Sheikhshoaie

  2. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Hadi Beitollahi

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  1. Fariba Garkani Nejad
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Correspondence to Iran Sheikhshoaie or Hadi Beitollahi.

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Fariba Garkani Nejad, Sheikhshoaie, I. & Beitollahi, H. A Screen-Printed Electrochemical Sensor Based on Iron Molybdenum Oxide Magnetic Nanocomposite for Simultaneous Detection of Acetaminophen and Isoniazid. Russ J Electrochem 58, 823–834 (2022). https://doi.org/10.1134/S1023193522090129

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