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Electrochemical reduction of ciprofloxacin at the mercury electrode and its voltammetric determination in tablet and urine

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Abstract

In this study a reduction square wave voltammetric method was developed and validated for the direct determination of ciprofloxacin (CIP) in pharmaceutical formulation and biological fluid using hanging mercury dropping electrode (HMDE) surface. Best results were obtained for the quantitative determination of CIP in 0.02 M Britton-Robinson buffer at pH 2.5 and at a potential of −1300 mV vs. Ag/AgCl reference electrode. Various experimental and instrumental parameters affecting the peak current and potential of CIP electrochemical reduction were investigated and optimized. The monitored peak current was directly proportional to the concentration of CIP, where it exhibited a linear response in the range 3.0 × 10−7–2 × 10−6 M (r = 0.99). The accuracy of the proposed method was concluded based on the value of mean recovery of 98 ± 0.72 % with RSD of 0.181 % at a detection limit of 7 × 10−9 M. Possible interferences by various substances usually present in pharmaceutical formulations have been also evaluated. After validating the proposed method, the applicability of this voltammetric method was demonstrated by estimating CIP in its pharmaceutical formulation and spiked human urine, where values of mean recoveries of 97 ± 1.0% and 108.0 ± 2.0% were obtained, respectively.

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References

  1. Sanghavi, B.J., Mobin, S.M., Mathur, P., Lahiri, G.K., and Srivastava, A.K., Biosens. Bioelectron., 2013, vol. 39, pp. 124–132.

    Article  CAS  Google Scholar 

  2. Sanghavi, B.J. and Srivastava, A.K., Electrochim. Acta, 2011, vol. 56, pp. 4188–4196.

    Article  CAS  Google Scholar 

  3. Sanghavi, B.J. and Srivastava, A.K., Anal. Chim. Acta, 2011, vol. 706, pp. 246–254.

    Article  CAS  Google Scholar 

  4. Dincel, A., Yildirim, A., Caglayan, F., and Bozkurt, A., Acta Chromatographica, 2005, vol. 15, pp. 308–314.

    CAS  Google Scholar 

  5. Lode, H., Hoffken, G., Prinzing, C., Glatzel, P., and Wiley, R., J. Clin. Chem. Biochem., 1986, vol. 24, pp. 325–331.

    Google Scholar 

  6. Kassab, N. M., Singh, A. K., Maria, E. R., and Santoro, M. I., Brazil. J. Pharma. Sci., 2005, vol. 41, pp. 507–513.

    CAS  Google Scholar 

  7. Sibinovic, P., Smelcerovic, A., Palic, R., Dordevic, S., and Marinkovic, V., J. Serb. Chem. Soc., 2005, vol. 70, pp. 979–986.

    Article  CAS  Google Scholar 

  8. Vybiralova, Z., Nobilis, M., Zoulora, J., Kvetina, J., and Petr, P., J. Pharma. Biomed. Anal., 2005, vol. 37, pp. 851–585.

    Article  CAS  Google Scholar 

  9. Kamberi, M., Tsutsumi, K., Kotegawa, T., Nakamura, K., and Nakano, S., Clin. Chem., 1998, vol. 44, pp. 1251–1255.

    CAS  Google Scholar 

  10. Navalon, A., Ballesteros, O., Blanc, R., and Vilchez, J., Talanta, 2000, vol. 52, pp. 845–852.

    Article  CAS  Google Scholar 

  11. Basavaiah, K., Nagegowda, P., Somashekar, B.C., and Ramakrishna, V., Sci. Asia, 2006, vol. 32, pp. 403–409.

    Article  CAS  Google Scholar 

  12. Abdel-Gawad, F.M., Issa, Y.M., Fahmy, H.M., and Hussein, H.M., MicroChimica Acta, 1998, vol. 130, pp. 35–40.

    Article  CAS  Google Scholar 

  13. Diao, Y.H., Chin. J. Hosp. Pharmm., 1994, vol. 14, pp. 212–214.

    CAS  Google Scholar 

  14. Ensafi, A.A., Taei, M., Khayamian, T., and Hasanpour, F., Anal. Sci., 2010, vol. 26, p. 803.

    Article  CAS  Google Scholar 

  15. Yi, H. and Li, C., Russ. J. Electrochem., 2007, vol. 43, pp. 1377–1381.

    Article  CAS  Google Scholar 

  16. Zhang, S. and Wei, S., Bull. Korean Chem. Soc., 2007, vol. 28, pp. 543–546.

    Article  CAS  Google Scholar 

  17. O’Dea, P., Garcia, A., Ordieres, A., Blanco, P., and Smyth, M., Electroanalysis, 1990, vol. 2, pp. 637–641.

    Article  Google Scholar 

  18. Uslu, B., Bozal, B., and Kuscu, M., Open Chem. Biomed. Meth. J., 2010, vol. 3, pp. 108–114.

    Article  CAS  Google Scholar 

  19. O’Dea, P., Garcíc, A.C., Ordieres, A.J., Blanco, P.T., and Smyth, M.R., Electroanal., 1991, vol. 3, pp. 337–342.

    Article  Google Scholar 

  20. Komorsky-Lovrić, S. and Nigović, B., J. Pharm Biomed Anal., 2004, vol. 36, pp. 81–89.

    Article  Google Scholar 

  21. Nelson, J.M., Chiller, T.M., Powers, J.H., and Angulo, F.J., Clin Infect Dis., 2007, vol. 44, pp. 977–980.

    Article  CAS  Google Scholar 

  22. Kawahara, S., Nippon Rinsho, 1998, vol. 56, pp. 3096–3099.

    CAS  Google Scholar 

  23. Drlica, K. and Zhao, X.K., Microbiol. Mol. Biol. Rev., 1997, vol. 61, pp. 377–392.

    CAS  Google Scholar 

  24. Stubauer, G. and Obendorf, D., Analyst, 1996, vol. 121, pp. 351–356.

    Article  CAS  Google Scholar 

  25. Wang, J., Stripping Analysis, Principles, Instrumentation and Applications, Florida: VCH Publishers, Inc. Deerfeild Beach, 1985.

    Google Scholar 

  26. Laviron, E., J. Electroanal. Chem., 1980, vol. 122, p. 11.

    Article  Google Scholar 

  27. ICH Harmonised Tripartite Guideline Q2 (R1) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, Validation of Analytical Procedures: Text and Methodology, International Conference on Harmonization, Switzerland, 2005.

  28. The United States Pharmacopoeia 29, The National Formulary 24, U.S. Pharmacopeial Convention, Rockville MD, 2006, pp. 3050–3053.

  29. Ermer, J., J. Pharm. Biomed. Anal., 2001, vol. 24, pp. 755–767.

    Article  CAS  Google Scholar 

  30. Taverniers, I., Loose, D.M., and Bockstaele, E.V., Trends in Analytical Chemistry, 2004, vol. 23, pp. 535–552.

    Article  CAS  Google Scholar 

  31. Suslu, I., Ozaltιn, N., and Altιnoz, S., J. Appl. Electrochem., 2009, vol. 39, pp. 1535–1543. The United States Pharmacopoeia 29, The National Formulary 24, U.S. Pharmacopeial Convention, Rockville MD, 2006, 3050–3053.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah, 30002, Saudi Arabia

    Ali F. Al-Ghamdi & Abdulilah Dawoud Bani-Yaseen

Authors
  1. Ali F. Al-Ghamdi
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  2. Abdulilah Dawoud Bani-Yaseen
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Correspondence to Ali F. Al-Ghamdi.

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Published in Russian in Elektrokhimiya, 2014, Vol. 50, No. 4, pp. 398–406.

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Al-Ghamdi, A.F., Bani-Yaseen, A.D. Electrochemical reduction of ciprofloxacin at the mercury electrode and its voltammetric determination in tablet and urine. Russ J Electrochem 50, 355–362 (2014). https://doi.org/10.1134/S1023193514040028

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  • DOI: https://doi.org/10.1134/S1023193514040028

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