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New adsorptive square wave method for trace determination of prilocain in the flow injection system by a fast fourier analysis

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Abstract

The determination of prilocain, used to manage tonic-clonic seizures, has been carried out at micro gold electrode (Au UME) using continuous fast Fourier transform square wave voltammetry. The Au UME electrode exhibited an effective response towards prilocaine adsorption. The peak current was also found to be significantly increased. The determination was carried out in phosphate containing electrolyte in the pH of 2.0 and a well-defined change on the peak current were noticed. The peak current was found to be linearly dependent on concentration of prilocain in the concentration range 5.0 × 10−7–1.0 × 10−11 M with a detection limit of 5.0 × 10−12 M. This paper describes development of a new analysis system to determine of prilocain by a novel square wave voltammetry method to perform a very sensitive method. The method used for determination of prilocain by measuring the changes in admittance voltammogram of a gold ultramicroelectrode (in 0.05 M H3PO4 solution) caused by adsorption of the prilocain on the electrode surface. Variation of admittance in the detection process is created by inhibition of oxidation reaction of the electrode surface, by adsorbed of prilocain. Furthermore, signal-to-noise ratio has significantly increased by application of discrete Fast Fourier Transform (FFT) method, background subtraction and two-dimensional integration of the electrode response over a selected potential range and time window. Also in this work some parameters such as SW frequency, eluent pH, and accumulation time were optimized. The relative standard deviation at concentration 5.0 × 10−8 M is 5.8% for 5 reported measurements.

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Authors and Affiliations

  1. Center of Excellence in Electrochemistry, Department of Chemistry, University of Tehran, Tehran, Iran

    Parviz Norouzi & Mohammad Reza Ganjali

  2. Endocrinology & Metabolism Research Center, Tehran University of Medical Science, Tehran, Iran

    Parviz Norouzi & Mohammad Reza Ganjali

  3. Medicinal Nanotechnology Research Center, University of Tehran Medical Science, Tehran, Iran

    Rassoul Dinarvand

  4. Forensic Department, Police University, Tehran, Iran

    Mohammad Hasan Eshraghi

  5. Quchan Branch, Department of Applied Chemistry, Islamic Azad University, Quchan, Iran

    Hassan Ali Zamani

Authors
  1. Parviz Norouzi
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  2. Mohammad Reza Ganjali
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  3. Rassoul Dinarvand
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  4. Mohammad Hasan Eshraghi
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  5. Hassan Ali Zamani
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Correspondence to Parviz Norouzi.

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Norouzi, P., Ganjali, M.R., Dinarvand, R. et al. New adsorptive square wave method for trace determination of prilocain in the flow injection system by a fast fourier analysis. Russ J Electrochem 46, 999–1006 (2010). https://doi.org/10.1134/S1023193510090053

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  • DOI: https://doi.org/10.1134/S1023193510090053

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