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Novel method for the determination of trace amounts of metformin in its pharmaceutical formulation by fast Fourier continuous cyclic voltametric technique at Au microelectrode in flowing solutions

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Abstract

An easy and fast Fourier transform continuous cyclic voltametric technique for monitoring of ultra trace amounts of metformin in a flow-injection system has been introduced in this work. The potential waveform, consisting of the potential steps for cleaning, stripping and potential ramp, was continuously applied on an Au disk microelectrode (12.5 μm in radius). The proposed detection method has some of advantages, the greatest of which are as follows: first, it is no more necessary to remove oxygen from the analyte solution and second, this is a very fast and appropriate technique for determination of the drug compound in a wide variety of chromatographic analysis methods. The detection limit for metformin was 43 pg/ml. The relative standard deviation (RSD) of the proposed technique at 5.0 × 10−7 M was 2.2% for 10 runs. The influences of pH of eluent, accumulation potential, sweep rate, and accumulation time on the determination of the metformin were considered. The proposed method was applied to the determination of metformin in a pharmaceutical preparation.

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Authors and Affiliations

  1. Center of Excellence in Electrochemistry, Department of Chemistry, University of Tehran, Tehran, Iran

    Mohammad Reza Ganjali, Parviz Norouzi & Mashalah Zare

Authors
  1. Mohammad Reza Ganjali
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  2. Parviz Norouzi
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  3. Mashalah Zare
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Correspondence to Mohammad Reza Ganjali.

Additional information

Published in Russian in Elektrokhimiya, 2008, Vol. 44, No. 10, pp. 1221–1230.

The text was submitted by the authors in English.

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Ganjali, M.R., Norouzi, P. & Zare, M. Novel method for the determination of trace amounts of metformin in its pharmaceutical formulation by fast Fourier continuous cyclic voltametric technique at Au microelectrode in flowing solutions. Russ J Electrochem 44, 1135–1143 (2008). https://doi.org/10.1134/S102319350810008X

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  • DOI: https://doi.org/10.1134/S102319350810008X

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