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Expression Profile and Relationships between microRNAs as Biomarkers in COPD Patients

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Abstract

Chronic obstructive pulmonary disease is a chronic inflammatory lung disease that causes airflow obstruction in the lungs. In fact, it is a lung disease that can cause involvement of respiratory tracts, lung tissue or blood vessels. There is still no accurate diagnostic tool for COPD. Among various biomarkers, the current review focuses on different types of miRNAs in COPD which have been studied. Many target cells and molecules, microRNAs are involved in the pathogenesis of COPD. MicroRNAs are a group of protected short single-stranded RNAs between 19 and 23 nucleotides and non-coding, which act as post-transcriptional regulators in animals, plants and viruses. In this article, the aim is to collect and categorize the studies conducted in the field of microRNA as biomarkers in COPD patients.

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This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Microbiology, School of Biological Sciences, North Tehran Branch, Islamic Azad University, 1956944413, Tehran, Iran

    N. Moattar-Husseini & F. Hosseini

  2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, 1956944413, Tehran, Iran

    N. Bahrami

  3. Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, 1956944413, Tehran, Iran

    N. Bahrami

  4. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, 1956944413, Tehran, Iran

    H. Jamaati & A. Mohamadnia

  5. Mycobacteriology Research Center, Biostatistics Unit, NRITLD, Shahid Beheshti University of Medical Sciences, 1956944413, Tehran, Iran

    M. Kazempour-Dizaji

  6. Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, 1956944413, Tehran, Iran

    Sh. Shafaghi & S. Noorali

  7. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, 1956944413, Tehran, Iran

    A. Mohamadnia

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  1. N. Moattar-Husseini
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Moattar-Husseini, N., Bahrami, N., Hosseini, F. et al. Expression Profile and Relationships between microRNAs as Biomarkers in COPD Patients. Russ J Genet 60, 433–449 (2024). https://doi.org/10.1134/S1022795424040082

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