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Association between the XRCC3 rs861539 Polymorphism and Breast Cancer Risk: An Updated Meta-Analysis

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Abstract

X-ray repair cross-complementing Group 3 (XRCC3) plays an important role in the repair of DNA double-strand breaks. Since it has been reported that breast cancer patients might be deficient in DNA damage repair, previous studies focused on the associations of the XRCC3 Thr241Met polymorphism and breast cancer risk. However, the results are controversial. Hence, we designed this meta-analysis to accurately evaluate the association between an XRCC3 polymorphism and breast cancer. To better understand the association between the rs861539 polymorphism and breast cancer, we performed this comprehensive meta-analysis of 28 852 patients and 30 176 controls. In general, no obvious association was found between the rs861539 polymorphism and breast cancer, but rs861539 was significantly associated with higher breast cancer risk among Asian individuals in a subgroup analysis in all models, especially in the homozygote model (TT vs. CC: OR = 2.142, 95% CI 1.516–3.026). A trend of increased risk of breast cancer was observed based on four other models in addition to the heterozygote model in a mixed population. No association was found between the rs861539 polymorphism and breast cancer in either Caucasian or African individuals. Our meta-analysis proved that the rs861539 polymorphism is closely associated with breast cancer risk in Asian individuals. Further studies should be conducted to confirm our conclusion and explore more associations that may exist between the rs861539 polymorphism and breast cancer subtypes.

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  1. Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, 430016, Wuhan, Hubei, China

    G. Hu, L. L. Gong, Y. J. Chen, L. H. Xu & C. M. Ye

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Hu, G., Gong, L.L., Chen, Y.J. et al. Association between the XRCC3 rs861539 Polymorphism and Breast Cancer Risk: An Updated Meta-Analysis. Russ J Genet 59 (Suppl 2), S219–S226 (2023). https://doi.org/10.1134/S1022795423140053

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