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Frequencies of Y-Chromosome Haplogroups and Migration Processes in Three Generations of Moscow Residents

  • HUMAN GENETICS
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Abstract

In three samples from the Moscow population representing three conditional generations, genotyping was carried out for 18 STR of the Y-chromosome and data on genetic demography were collected by means of a questionnaire. Comparative statistical analysis revealed spectra and frequency profiles of Y-chromosome haplogroups characteristic for each generation and demonstrated significant differences between the two older generations and the younger generation of Moscow residents, in particular, in the frequency of haplogroup N. In the younger generation, statistically significant accumulation of haplogroups of “southern origin” brought with the flows of migrants was shown. In the three generations of Muscovites, features of the Y‑chromosome haplogroup frequency distribution are in good agreement with the parameters of migration flows to Moscow during recent decades and with survey data on the migrant places of origin and ethnic composition. The results of the study indicate the necessity of permanent updating and actualization of population reference databases for the purposes of DNA-based identification in megacities, as well as the necessity of accomplishing molecular genetic analysis by the data on genetic demography obtained by questionnaire survey.

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ACKNOWLEDGMENTS

We thank the Muscovites who took part in the survey and provided their biological samples, as well as the management of medical institutions in Moscow for valuable collaboration and their help with the collection of materials.

Funding

The present study was conducted within the framework of the Scientific and Technical Program of the Union State “Development of Innovative Gene Geographical and Genomic Technologies for Identifying and Revealing Personal Features by Studying the Gene Pools of the Regional Populations of the Union State” (“DNA Identification”, Event 10).

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Authors and Affiliations

  1. Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia

    I. G. Udina, A. S. Gracheva & O. L. Kurbatova

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  1. I. G. Udina
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  2. A. S. Gracheva
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  3. O. L. Kurbatova
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Correspondence to I. G. Udina.

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Conflict of interest. The authors declare no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee at the Vavilov Institute of General Genetics. Informed consent was obtained from all individual participants involved in the study (in the sample of newborns, consent was obtained from their mothers). Demographic data obtained during the survey and the results of the study are presented and stored in an anonymous (depersonalized) form.

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Translated by A. Kazantseva

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Udina, I.G., Gracheva, A.S. & Kurbatova, O.L. Frequencies of Y-Chromosome Haplogroups and Migration Processes in Three Generations of Moscow Residents. Russ J Genet 58, 1365–1372 (2022). https://doi.org/10.1134/S1022795422110114

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