Skip to main content
SpringerLink
Log in

Expression of the β1 Adrenergic Receptor Gene (ADRB1) in the Myocardium of Patients with Chronic Heart Failure

  • HUMAN GENETICS
  • Published:
Russian Journal of Genetics Aims and scope Submit manuscript

Abstract

An analysis of the level of relative expression of the β1 adrenergic receptor ADRB1 gene in the myocardium of 78 patients with chronic heart failure against the background of the combined development of ischemic heart disease and arterial hypertension was carried out. A significant decrease in the level of ADRB1 gene expression was revealed in patients with left ventricular hypertrophy. In the considered cohort, the expression level of the ADRB1 gene did not depend on the functional class of heart failure. The ADRB1 relative expression was higher in patients taking acetylsalicylic acid preparations, but did not show a significant association with the use of β blockers or ACE inhibitors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

REFERENCES

  1. Ranade, K., Jorgenson, E., and Sheu, W.H.-H., et al., A polymorphism in the β1 adrenergic receptor is associated with resting heart rate, Am. J. Hum. Genet., 2002, vol. 70, no. 4, pp. 935–942. https://doi.org/10.1086/339621

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Kostyukevich, M.V., Zykov, K.A., Mironova, N.A., et al., Role of autoantibodies against ßJ-adrenergic receptor in cardiovascular disease, Kardiologiya, 2016, vol. 56, no. 12, pp. 82–91. https://doi.org/10.18565/cardio.2016.12.82-91

    Article  CAS  PubMed  Google Scholar 

  3. Luo, W., Grupp, I.L., Harrer, J., et al., Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of 3-agonist stimulation, Circ. Res., 1994, vol. 75, no. 3, pp. 401–409. https://doi.org/10.1161/01.RES.75.3.401

    Article  CAS  PubMed  Google Scholar 

  4. Zhihao, L., Jingyu, N., Lan, L., et al., SERCA2a: a key protein in the Ca2+ cycle of the heart failure, Heart Failure Rev., 2020, vol. 25, pp. 523–535. https://doi.org/10.1007/s10741-019-09873-3

    Article  CAS  Google Scholar 

  5. Najafi, A., Sequeira, V., Kuster, D.W.D., and van der Velden, J., β-Adrenergic receptor signalling and its functional consequences in the diseased heart, Eur. J. Clin. Invest., 2016, vol. 46, no. 4, pp. 362–374. https://doi.org/10.1111/eci.12598

    Article  CAS  PubMed  Google Scholar 

  6. Zhu, W.Z., Wang, S.Q., Chakir, K., et al., Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II, J. Clin. Invest., 2003, vol. 111, no. 5, pp. 617–625. https://doi.org/10.1172/JCI16326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Frielle, T., Collins, S., Daniel, K.W., et al., Cloning of the cDNA for the human beta1-adrenergic receptor, Proc. Natl. Acad. Sci. U.S.A., 1987, vol. 84, no. 22, pp. 7920–7924. https://doi.org/10.1073/pnas.84.22.7920

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Yang-Feng, T.L., Xue, F.Y., Zhong, W.W., et al., Chromosomal organization of adrenergic receptor genes, Proc. Natl. Acad. Sci. U.S.A., 1990, vol. 87, no. 4, pp. 1516–1520. https://doi.org/10.1073/pnas.87.4.1516

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kuznetsova, O.O., Nikulina, S.Yu., Chernova, A.A., et al., The role of β-1-adrenergic receptor gene polymorphism in the development of dilated cardiomyopathy, Ross. Med. Zh.: Med. Obozr., 2020, vol. 4, no. 7, pp. 394–398. https://doi.org/10.32364/2587-6821-2020-4-7-394-398

    Article  Google Scholar 

  10. Yakushin, S.S. and Solodun, M.V., β1-Adrenergic receptor gene polymorphism, postinfarction myocardial remodeling and cardiovascular risk: is there a relationship?, Med. Sovet, 2018, no. 5, pp. 42–46. https://doi.org/10.21518/2079-701X-2018-5-42-46

  11. Vanderheyden, M., Mullens, W., Delrue, L., et al., Endomyocardial upregulation of beta1 adrenoreceptor gene expression and myocardial contractile reserve following cardiac resynchronization therapy, J. Card. Failur, 2008, vol. 14, no. 2, pp. 172—178. https://doi.org/10.1016/j.cardfail.2007.10.016

    Article  CAS  Google Scholar 

  12. Mareev, V.Yu., Fomin, I.V., Ageev, F.T., et al., Clinical recommendations of Heart Failure Society, Russian Society of Cardiology, and Russian Scientific Medical Society of Therapists: heart failure: chronic (CHF) and acute decompensated (ADHF): diagnostics, prophylaxis and treatment, Kardiologiya, 2018, vol. 58, no. 6, pp. 3–164. https://doi.org/10.18087/cardio.2475

    Article  Google Scholar 

  13. Muslimova, E.F., Rebrova, T.Y., Kondratieva, D.S., et al., Expression of the Ca2+-ATPase SERCA2a (ATP2A2) gene and the ryanodine receptor (RYR2) gene in patients with chronic heart failure, Russ J Genet., 2020, vol. 56, no. 7, pp. 843–848. https://doi.org/10.1134/S1022795420070108

    Article  CAS  Google Scholar 

  14. Li, M., Rao, M., Chen, K., et al., Selection of reference genes for gene expression studies in heart failure for left and right ventricles, Gene, 2017, vol. 620, pp. 30–35. https://doi.org/10.1016/j.gene.2017.04.006

    Article  CAS  PubMed  Google Scholar 

  15. Molina, C.E., Jacquet, E., Ponien, P., et al., Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart, Cardiovasc. Res., 2018, vol. 114, no. 2, pp. 247–258. https://doi.org/10.1093/cvr/cvx182

    Article  CAS  PubMed  Google Scholar 

  16. Pfaffl, M.W., Quantification strategies in real-time PCR, in A-Z of Quantitative PCR, La Jolla, CA, 2004, pp. 87—112.

  17. Lohse, M.J., Engelhardt, S., and Eschenhagen, T., What is the role of β-adrenergic signaling in heart failure?, Circ. Res., 2003, vol. 93, no. 10, pp. 896—906. https://doi.org/10.1161/01.RES.0000102042.83024.CA

    Article  CAS  PubMed  Google Scholar 

  18. Brodde, O.-E., β1- and β2-adrenoceptor polymorphisms and cardiovascular diseases, Fundam. Clin. Pharmacol., 2008, vol. 22, no. 2, pp. 107–125. https://doi.org/10.1111/j.1472-8206.2007.00557.x

    Article  CAS  PubMed  Google Scholar 

  19. Greenberg, B., Yaroshinsky, A., Zsebo, K.M., et al., Design of a phase 2b trial of intracoronary administration of AAV1/SERCA2a in patients with advanced heart failure: the CUPID 2 Trial (calcium up-regulation by percutaneous administration of gene therapy in cardiac disease phase 2b), JACC: Heart Failure, 2014, vol. 2, no. 1, pp. 84–92. https://doi.org/10.1016/j.jchf.2013.09.008

    Article  PubMed  Google Scholar 

  20. Cohn, J.N., Levine, T.B., Olivari, M.T., et al., Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure, N. Engl. J. Med., 1984, vol. 311, pp. 819–823. https://doi.org/10.1056/NEJM198409273111303

    Article  CAS  Google Scholar 

  21. Mitral’naya regurgitatsiya. Klinicheskie rekomendatsii (Mitral Regurgitation: Clinical Guidelines), Ministerstvo Zdravookhraneniya Rossiiskoi Federatsii, 2016. https://racvs.ru/clinic/files/2016/mitral-regurg.pdf.

Download references

Funding

This study was supported by a grant from the Russian Science Foundation (project no. 20-75-00003): “Assessment of the Association of Expression of Genes of Ca (2+)-Transporting Proteins of the Sarcoplasmic Reticulum of Cardiomyocytes with the Severity of Chronic Heart Failure of Ischemic Origin.”

Author information

Authors and Affiliations

  1. Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012, Tomsk, Russia

    E. F. Muslimova, T. Yu. Rebrova, D. S. Kondratieva, E. L. Sonduev, B. N. Kozlov & S. A. Afanasiev

Authors
  1. E. F. Muslimova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Yu. Rebrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. S. Kondratieva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. L. Sonduev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. N. Kozlov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. A. Afanasiev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. F. Muslimova.

Ethics declarations

Conflict of interest. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in a study involving people comply with the ethical standards of the institutional and/or national committee for research ethics and the 1964 Helsinki Declaration and its subsequent changes or comparable ethical standards.

Informed voluntary consent was obtained from each of the participants.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Muslimova, E.F., Rebrova, T.Y., Kondratieva, D.S. et al. Expression of the β1 Adrenergic Receptor Gene (ADRB1) in the Myocardium of Patients with Chronic Heart Failure. Russ J Genet 57, 1304–1311 (2021). https://doi.org/10.1134/S1022795421110089

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1022795421110089

Keywords:

Search

Navigation