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Features of the Genomic Distribution of Runs of Homozygosity in the Indigenous Population of Northern Eurasia at the Individual and Population Levels Based on High Density SNP Analysis

  • HUMAN GENETICS
  • Published:
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Abstract

The genomic data analysis (~886 889 autosomal SNPs) allowed us to estimate the inbreeding level on the basis of the analysis of runs of homozygosity (FROH) in a sample of 1836 individuals, including 76 indigenous populations of Siberia, Dagestan, the Caucasus, Volga-Ural region, Eastern Europe, and Central Asia. The data were obtained using the Infinium Multi-Ethnic Global-8 Kit. In the populations of Dagestan, within the Nakh-Daghestanian language family, representatives of several language groups can be distinguished, with the maximum FROH level for the Dido group (0.0727) and the Andean group (0.0378), which is similar in values to the populations speaking the Chukchi-Kamchatka and Nivkh languages of Siberia (0.0360). The Siberian populations are characterized by a greater value of the total length of short and medium runs of homozygosity per person. The total length of long ROHs is more variable and much larger in the most of the populations of Dagestan and Siberia compared to other populations of the Caucasus, Central Asia, Europe, and the Volga-Ural region.

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Funding

The present study was supported by the Russian Foundation for Basic Research (project no. 19-34-90101).

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Authors and Affiliations

  1. Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050, Tomsk, Russia

    N. A. Kolesnikov, V. N. Kharkov, A. A. Zarubin & V. A. Stepanov

  2. Amirkhanov Institute of Physics, Dagestan Federal Research Center, Russian Academy of Sciences, 367012, Makhachkala, Russia

    M. O. Radzhabov

  3. Federal Research Center of Fundamental and Translational Medicine, 630060, Novosibirsk, Russia

    M. I. Voevoda

  4. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    M. A. Gubina

  5. Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences, 450054, Ufa, Russia

    E. K. Khusnutdinova, S. S. Litvinov & N. V. Ekomasova

  6. Katanov Khakass State University, 655000, Abakan, Russia

    O. V. Shtygasheva

  7. Ammosov North-Eastern Federal University, 677000, Yakutsk, Russia

    N. R. Maksimova & A. L. Sukhomyasova

Authors
  1. N. A. Kolesnikov
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  2. V. N. Kharkov
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  3. A. A. Zarubin
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  4. M. O. Radzhabov
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  5. M. I. Voevoda
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  6. M. A. Gubina
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  7. E. K. Khusnutdinova
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  8. S. S. Litvinov
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  9. N. V. Ekomasova
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  10. O. V. Shtygasheva
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  11. N. R. Maksimova
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  12. A. L. Sukhomyasova
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  13. V. A. Stepanov
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Correspondence to N. A. Kolesnikov.

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Conflict of interest. The authors declare no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by A. Kazantseva

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Kolesnikov, N.A., Kharkov, V.N., Zarubin, A.A. et al. Features of the Genomic Distribution of Runs of Homozygosity in the Indigenous Population of Northern Eurasia at the Individual and Population Levels Based on High Density SNP Analysis. Russ J Genet 57, 1271–1284 (2021). https://doi.org/10.1134/S1022795421110053

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